Clinicopathologic Features and Prognostic Significance of Immunohistochemistry and In Situ Hybridization Based Molecular Classification in Gastric Carcinoma

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dc.authoridGuvendir Bakkaloglu, Irem/0000-0002-2558-786Xen_US
dc.authoridNARLİ ISSİN, gizem/0000-0002-3688-2768en_US
dc.authoridZemheri, Itır Ebru/0000-0003-0247-0332en_US
dc.authorscopusid57214775911en_US
dc.authorscopusid55945180700en_US
dc.authorscopusid57203981572en_US
dc.authorscopusid58508094500en_US
dc.authorscopusid6507031438en_US
dc.authorscopusid57937534600en_US
dc.authorscopusid56494353000en_US
dc.authorwosidGuvendir Bakkaloglu, Irem/IWL-9126-2023en_US
dc.authorwosidNARLİ ISSİN, gizem/IQS-2333-2023en_US
dc.authorwosidZemheri, Itır Ebru/JRY-6674-2023en_US
dc.contributor.authorIssin, Gizem
dc.contributor.authorSayar, Ilyas
dc.contributor.authorDemir, Fatih
dc.contributor.authorBakkaloglu, Irem Guvendir
dc.contributor.authorGamsizkan, Mehmet
dc.contributor.authorYildiz, Zeliha
dc.contributor.authorYilmaz, Ismail
dc.date.accessioned2024-08-23T16:03:54Z
dc.date.available2024-08-23T16:03:54Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground/Aim: Gastric carcinoma (GC) is a highly heterogeneous disease with many subtypes that have different morphologic and molecular characteristics. In the current study, we analyzed immunohistochemical (IHC) and in situ hybridization (ISH) features of GCs and evaluated their association with prognosis and clinicopathological features. Materials and Methods: Three hundred cases analyzed by IHC and ISH for microsatellite stability, p53, e-cadherin, HER2, PD-L1 expression, and Epstein-Barr virus (EBV) status. Cases were classified into five subgroups based on expression profile. The relationships between subgroups, clinicopathological features, and survival were determined. Results: Ten ( 3.3%) cases were classified as EBV-associated, 45 (15%) as microsatellite instable (MSI), 73 (24.3%) as EBV-/ microsatellite-stable (MSS)/epithelial-mesenchymal-transformation (EMT)-like, 75 (25%) as EBV-/MSS/ non-EMT-like/p53+, and 97 (32.3%) as EBV-/MSS/non-EMT-like/ p53-. The MSI subtype had the best overall survival (OS). In contrast, the EBV-/MSS/EMT-like subtype had the poorest OS. The MSI subtype was also related with old age of the patient and antrum-corpus localized tumors, whereas the EBV-/MSS/EMT-like was associated with young age, larger tumor size, and advanced stage presentation. PD-L1 positivity is highly correlated with MSI and EBV-associated subtypes. Conclusion: Our data demonstrated a link between IHC/ISH characteristics of GC and clinical outcomes. IHC/ISH based molecular classification may be helpful in predicting the survival.en_US
dc.description.sponsorshipErzincan University Scientific Research and Project Office [768]en_US
dc.description.sponsorshipThis study was supported by Erzincan University Scientific Research and Project Office (Project ID: 768).en_US
dc.identifier.doi10.1615/JEnvironPatholToxicolOncol.2023047662
dc.identifier.endpage14en_US
dc.identifier.issn0731-8898
dc.identifier.issn2162-6537
dc.identifier.issue4en_US
dc.identifier.pmid37522564en_US
dc.identifier.scopus2-s2.0-85165892012en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1615/JEnvironPatholToxicolOncol.2023047662
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13979
dc.identifier.volume42en_US
dc.identifier.wosWOS:001074432700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBegell House Incen_US
dc.relation.ispartofJournal of Environmental Pathology Toxicology And Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmolecular classification of gastric carcinomaen_US
dc.subjectEBV associated gastric canceren_US
dc.subjectmicrosatellite instabilityen_US
dc.subjectCDH1 mutationen_US
dc.subjectabnormal e-cadherin expressionen_US
dc.subjectabnormal p53 expressionen_US
dc.subjectExpression-Based Classificationen_US
dc.subjectMicrosatellite Instabilityen_US
dc.subjectCanceren_US
dc.subjectSubtypesen_US
dc.subjectMetaanalysisen_US
dc.subjectProteinen_US
dc.titleClinicopathologic Features and Prognostic Significance of Immunohistochemistry and In Situ Hybridization Based Molecular Classification in Gastric Carcinomaen_US
dc.typeArticleen_US

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