Effect of smoking intensity on thyroid volume, thyroid nodularity and thyroid function: the Melen study

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dc.contributor.authorAydın, Leyla Yılmaz
dc.contributor.authorAydın, Yusuf
dc.contributor.authorBeşir, Fahri Halit
dc.contributor.authorDemirin, Hilmi
dc.contributor.authorYıldırım, H.
dc.contributor.authorÖnder, Elif
dc.contributor.authorCelbek, Gökhan
dc.date.accessioned2020-05-01T09:11:46Z
dc.date.available2020-05-01T09:11:46Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000301170200002en_US
dc.descriptionPubMed: 22322651en_US
dc.description.abstractAim. The purpose of our study was to determine the association between smoking habit, goiter, thyroid functions and ultrasonographic nodularity in moderately iodine deficient area. Methods. The MELEN study is a prospectively designed survey on the prevalence of thyroid diseases in Turkish adults. A total of 2298 subjects with a mean age of 50 (age range 18 to 92) were interviewed. Smoking habits were registered from questionnaires and subsequent interviews with a physician. Thyroid ultrasonography was performed and interpreted by the same experienced physician, using the same equipment. After an overnight fast, blood samples were collected from all the study subjects for the determination of serum free thyroxine, thyroid stimulating hormone (TSH) were measured. Results. Mean thyroid volumes of current smokers were significantly lower than either former or never smokers (P=0.014). There were no difference according to smoking habits on goiter and established multinodularity in current smokers (P<0.05). Heavy smokers (>20 pack/year) had higher thyroid volumes, higher goiter and multinodular goiter (MNG) prevalence than moderate smokers (P<0.001). Thyrotoxicosis (TSH<0.35) cases were more frequent among heavy smokers than moderate smokers (14.1% versus 8.2%, P<0.001; respectively). Heavy smoking independently predicted goiter (odds ratio: 1.459 [95% confidence interval: 1.029 and 2.068]; P=0.034). Conclusion. Heavy smoking was associated with increased prevalence of thyroid multinodularity and goiter in respect to moderate smoking. No association was found between smoking habit and thyroid dysfunction.en_US
dc.identifier.endpage280en_US
dc.identifier.issn0391-1977
dc.identifier.issn1827-1634
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage273en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5760
dc.identifier.volume36en_US
dc.identifier.wosWOS:000301170200002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofMinerva Endocrinologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGoiteren_US
dc.subjectSmokingen_US
dc.subjectThyroid function testsen_US
dc.titleEffect of smoking intensity on thyroid volume, thyroid nodularity and thyroid function: the Melen studyen_US
dc.typeArticleen_US

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