Expression of nucleolin, nucleophosmin, upstream binding transcription factor genes and propolis in wound models

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dc.authorwosidEr, Recep/HFZ-9751-2022
dc.contributor.authorKaya, Murat
dc.contributor.authorEröz, Recep
dc.contributor.authorKabaklıoğlu, Murat
dc.date.accessioned2023-07-26T11:57:16Z
dc.date.available2023-07-26T11:57:16Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Çocuk Cerrahi Ana Bilim Dalıen_US
dc.description.abstractObjective: Nucleolar proteins have important functions in the regulation of cell homeostasis and play a crucial role in sensing various types of stress, such as genotoxic stress. Propolis has epithelial, analgesic, antibacterial, antifungal and antiviral effects. This study aimed to evaluate the gene expression levels of nucleolar proteins: nucleolin (NCL); nucleophosmin (NPM1); and upstream binding transcription factor (UBTF), as well as the benefits of propolis in wound healing. Method: This experimental study was conducted by creating clean and clean-contaminated wounds according to the Surgical Site Infection Guidelines, 2016. A total of seven animal groups were included in the study: control; laparotomy; anastomosis; fucidic acid with/without anastomosis; propolis with/without anastomosis Results: Statistically significant differences of levels of gene expression among the groups were detected for NCL (p=0.004), NPM1 (p=0.011) and UBTF (p=0.000). When the expression levels of the related genes and blood parameters are considered, the relationship between NCL, NPM1 and UBTF expression levels and blood parameters (NE, EO, NE(%), LY, LY(%), EO, EO(%), MO, MO(%), RBC, HB, HCT, MCV, MCHC, RDW, RDW(%), PLT, PDW and PCT) were statistically significant. Conclusion: The nucleolar proteins such as NCL, NPM1 and UBTF have important functions in cell viability and its maintenance under various condition such as stress and injury. Additionally, propolis has positive benefits in wound healing and in the prevention of wound infection. Our findings provide the first insights into the putative role of those proteins in wound healing.en_US
dc.identifier.doi10.12968/jowc.2022.31.Sup10.S28
dc.identifier.endpageS40en_US
dc.identifier.issn0969-0700
dc.identifier.issn2062-2916
dc.identifier.issue10en_US
dc.identifier.pmid36240873en_US
dc.identifier.scopus2-s2.0-85140136253en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpageS28en_US
dc.identifier.urihttps://doi.org/10.12968/jowc.2022.31.Sup10.S28
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13099
dc.identifier.volume31en_US
dc.identifier.wosWOS:000871258600004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKaya, Murat
dc.institutionauthorKabaklıoğlu, Murat
dc.language.isoenen_US
dc.publisherMa Healthcare Ltden_US
dc.relation.ispartofJournal of Wound Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectAntibacterial; Antifungal; Antiviral; Bee Propolis; Gene Expression; Nucleolar Proteins; Nucleolin; Nucleophosmin; Upstream Binding Transcription Factors; Wound; Wound Care; Wound Dressing; Wound Healingen_US
dc.subjectProtein-Synthesis; Regionsen_US
dc.titleExpression of nucleolin, nucleophosmin, upstream binding transcription factor genes and propolis in wound modelsen_US
dc.typeArticleen_US

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