Tryptophan hydroxylase gene polymorphism in patients with obsessive-compulsive disorder

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dc.contributor.authorKorkmaz, Sevda
dc.contributor.authorÖnalan, Ebru
dc.contributor.authorYüce, Hüseyin
dc.contributor.authorAtmaca, Murad
dc.date.accessioned2020-04-30T23:46:49Z
dc.date.available2020-04-30T23:46:49Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000376662600002en_US
dc.description.abstractObjective: There is limited number of studies on the effects of tryptophan hydroxylase1 (TPH1) A218C gene polymorphism on obsessive-compulsive disorder (OCD) etiology. This study aims to scrutinize the role of TPH1-A218C gene polymorphism on OCD etiology. Methods: Sixty patients diagnosed with OCD, applied to our clinic and fitting the study criteria were accepted as patient group. A group of 60 healthy individuals matching the patient group in age and gender were selected as the control group. In the study the Clinical Interview Scale Structured for DSM-IV Axis-I Disorders, Socio-demographic and Clinical Data Form, Yale Brown Obsessive Compulsive Rating Scale (Y-BOCS) and Hamilton Depression Rating Scale were applied to participants initially. Consequently, they were classified into two groups of 'responsive to therapy' and 'resistant to therapy' based on their therapy histories and Y-BOCS points. For DNA isolation 300 mu l blood samples were used in compliance with standard methods. Restriction Fragment Length Polymorphism method was used to evaluate A218C polymorphism in TPH-1 gene within the blood samples. Results: No significant difference was observed between patient and control groups related to TPH-1 genotypes. However, a significant increase was observed in AA genotype frequency for TPH-1gene in the patient group resistant to therapy and in CC genotype frequency in the patient group responsive to therapy. The difference of the allele type ratios in this polymorphism between each patient group could be related to the response to therapy. To confirm the findings of the study, more research on the same gene polymorphisms is required with OCD patients in different societies.en_US
dc.identifier.doi10.5455/apd.180136en_US
dc.identifier.endpage92en_US
dc.identifier.issn1302-6631
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://doi.org/10.5455/apd.180136
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5274
dc.identifier.volume17en_US
dc.identifier.wosWOS:000376662600002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherCumhuriyet Univ Tip Fak Psikiyatri Anabilim Dalien_US
dc.relation.ispartofAnadolu Psikiyatri Dergisi-Anatolian Journal Of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectobsessive compulsive disorderen_US
dc.subjecttryptophan hydroxylase geneen_US
dc.subjectpolymorphismen_US
dc.titleTryptophan hydroxylase gene polymorphism in patients with obsessive-compulsive disorderen_US
dc.typeArticleen_US

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