The Role of Genetic, Environmental, and Dietary Factors in Alzheimer's Disease: A Narrative Review

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dc.authoridBOSGELMEZ, IFFET IPEK/0000-0003-2528-1227;
dc.contributor.authorMertas, Beyza
dc.contributor.authorBosgelmez, I. Ipek
dc.date.accessioned2025-10-11T20:47:48Z
dc.date.available2025-10-11T20:47:48Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractAlzheimer's disease (AD) is one of the most common and severe forms of dementia and neurodegenerative disease. As life expectancy increases in line with developments in medicine, the elderly population is projected to increase in the next few decades; therefore, an increase in the prevalence of some diseases, such as AD, is also expected. As a result, until a radical treatment becomes available, AD is expected to be more frequently recorded as one of the top causes of death worldwide. Given the current lack of a cure for AD, and the only treatments available being ones that alleviate major symptoms, the identification of contributing factors that influence disease incidence is crucial. In this context, genetic and/or epigenetic factors, mainly environmental, disease-related, dietary, or combinations/interactions of these factors, are assessed. In this review, we conducted a literature search focusing on environmental factors such as air pollution, toxic elements, pesticides, and infectious agents, as well as dietary factors including various diets, vitamin D deficiency, social factors (e.g., tobacco and alcohol use), and variables that are affected by both environmental and genetic factors, such as dietary behavior and gut microbiota. We also evaluated studies on the beneficial effects of antibiotics and diets, such as the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) and Mediterranean diets.en_US
dc.identifier.doi10.3390/ijms26031222
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.issue3en_US
dc.identifier.pmid39940989en_US
dc.identifier.scopus2-s2.0-85217777973en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/ijms26031222
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21566
dc.identifier.volume26en_US
dc.identifier.wosWOS:001418624500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectAlzheimer's diseaseen_US
dc.subjectrisk factorsen_US
dc.subjectexposomeen_US
dc.subjectgeneticsen_US
dc.subjectgut microbiotaen_US
dc.subjectinfectionsen_US
dc.subjectdieten_US
dc.titleThe Role of Genetic, Environmental, and Dietary Factors in Alzheimer's Disease: A Narrative Reviewen_US
dc.typeReviewen_US

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