Hydroxylated polymeric linolenic acid containing cytocompatible cryogels with antibiofilm activities

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dc.authoridAltintas, Fatih/0000-0001-8779-0110
dc.authoridSarkaya, Koray/0000-0003-0177-5134
dc.contributor.authorAlli, Abdulkadir
dc.contributor.authorSarkaya, Koray
dc.contributor.authorBozbeyoglu, Naime Nur
dc.contributor.authorAltintas, Fatih
dc.contributor.authorYardimci, Berna Kavakcioglu
dc.contributor.authorAlli, Sema
dc.contributor.authorKuzucu, Volkan
dc.date.accessioned2025-10-11T20:48:29Z
dc.date.available2025-10-11T20:48:29Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractEssential oils and their acids can possess various beneficial properties, such as antioxidant, antiviral, antifungal, and antibacterial activities. Therefore, we conducted a comprehensive examination of the biological activities of HEMA-based cryogels containing hydroxylated polymeric linolenic acid (PLinoOH). First, linolenic acid underwent autoxidation for three months to yield macroperoxide linolenic acid. This macro peroxide fatty acid, distinguished by its peroxide, epoxide, and hydroperoxide functional groups, reacted with diethanolamine to synthesize hydroxylated polymeric linolenic acid (PLinoOH). The resulting PLinoOH was then utilized to prepare the HEMA-based cryogel series. These cryogels were physically and chemically characterized. The cytocompatibility of the cryogel series and its potential genotoxic effects on cellular DNA were examined using human embryonic kidney cells. The antifungal and antibacterial effects of the cryogel series were evaluated against Saccharomyces cerevisiae yeast and Staphylococcus aureus, Enterococcus faecalis, and Pseudomonas aeruginosa bacterial strains. Additionally, total sugar, uronic acid, and protein analyses were performed to understand their effects on the exopolysaccharide substance in the biofilm structure. The fabricated cryogels exhibited considerable antibiofilm effects along with their remarkable biocompatibility. They showed varying effects were observed on the structure of exopolysaccharide substance according to the bacterial species and cell wall structure. Overall, these findings highlight the potentials of the fabricated cryogels as multifunctional biomaterials for combating microbial infections, with species-specific impacts on biofilm extracellular polymeric substance (EPS) composition.en_US
dc.description.sponsorshipDzce University Research Fund [2024.05.03.1541]en_US
dc.description.sponsorshipThis study was funded by the Duzce University Research Fund (Grant Number: 2024.05.03.1541) .en_US
dc.identifier.doi10.1016/j.mtchem.2025.102602
dc.identifier.issn2468-5194
dc.identifier.scopus2-s2.0-85218408723en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.mtchem.2025.102602
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21945
dc.identifier.volume44en_US
dc.identifier.wosWOS:001434741900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofMaterials Today Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectCryogelen_US
dc.subjectLinolenic aciden_US
dc.subjectAntimicrobial activityen_US
dc.subjectBiofilmen_US
dc.subjectComet assayen_US
dc.titleHydroxylated polymeric linolenic acid containing cytocompatible cryogels with antibiofilm activitiesen_US
dc.typeArticleen_US

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