The role of tranexamic acid and cryotherapy on acute postoperative pain and blood loss: a randomized controlled study following total knee arthroplasty

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dc.authoridDalaslan, Rasit Emin/0000-0001-5068-8024;
dc.contributor.authorSaglam, Soenmez
dc.contributor.authorKaraduman, Zekeriya Okan
dc.contributor.authorArican, Mehmet
dc.contributor.authorYucel, Muecahid Osman
dc.contributor.authorDalaslan, Rasit Emin
dc.contributor.authorCangur, Sengul
dc.contributor.authorUludag, Veysel
dc.date.accessioned2025-10-11T20:48:46Z
dc.date.available2025-10-11T20:48:46Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractPurpose Blood loss and pain management are significant concerns in total knee arthroplasty (TKA). Tranexamic acid (TA) and cryotherapy have been used separately to address these issues, but their comparative effectiveness is not well studied. This study aimed to evaluate the efficacy of intravenous TA and cryotherapy in reducing blood loss and improving clinical outcomes after TKA. Methods A randomized controlled trial with 76 patients assigned to three groups: Group 1 received pre- and postoperative cryotherapy, Group 2 received intravenous tranexamic acid (TA), and Group 3 (control) received a standard cold pack. Hemoglobin (Hb), hematocrit (Hct), prothrombin time, international normalized ratio (INR), knee flexion and extension angles, and visual analog scale (VAS) pain scores were monitored preoperatively and postoperatively at 6, 24, and 48 h. Results The mean age of patients was 65 +/- 7 years. The tranexamic acid group showed significantly lower blood loss compared to the control group (p < 0.001). Knee flexion and extension angles were significantly better in the cryotherapy group compared to the control group (p < 0.001). VAS pain scores were significantly lower in the cryotherapy group at all time points compared to both the tranexamic acid and control groups (p < 0.001). Conclusion Both tranexamic acid and cryotherapy are effective in reducing blood loss and improving clinical outcomes following TKA. Tranexamic acid significantly reduces blood loss, while cryotherapy effectively manages postoperative pain and range of motion. These methods can enhance patient recovery after TKA.en_US
dc.identifier.doi10.1007/s00590-025-04174-y
dc.identifier.issn1633-8065
dc.identifier.issn1432-1068
dc.identifier.issue1en_US
dc.identifier.pmid39862298en_US
dc.identifier.scopus2-s2.0-85216997760en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s00590-025-04174-y
dc.identifier.urihttps://hdl.handle.net/20.500.12684/22091
dc.identifier.volume35en_US
dc.identifier.wosWOS:001406493900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofEuropean Journal of Orthopaedic Surgeryand Traumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectBlood lossen_US
dc.subjectCryotherapyen_US
dc.subjectPain managementen_US
dc.subjectTotal knee arthroplastyen_US
dc.subjectTranexamic aciden_US
dc.titleThe role of tranexamic acid and cryotherapy on acute postoperative pain and blood loss: a randomized controlled study following total knee arthroplastyen_US
dc.typeArticleen_US

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