Effects of an Extract of Salvia Miltiorrhiza on a Penicillin-Induced Epilepsy Model in Rats

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dc.contributor.authorBahadır, Anzel
dc.contributor.authorDemir, Şerif
dc.contributor.authorOrallar, Hayriye
dc.contributor.authorBeyazçiçek, Ersin
dc.contributor.authorÖner, F.
dc.date.accessioned2020-05-01T09:11:52Z
dc.date.available2020-05-01T09:11:52Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionOrallar, Hayriye/0000-0002-0000-3768en_US
dc.descriptionWOS: 000361988900008en_US
dc.description.abstractIn a penciling-induced epilepsy model, Wistar rats (16 males, 16 females) were i.p. administered with an extract of Salvia miltiorrhiza (SmE; total dose 50 mg/kg) once a day for 15 days. The rats were divided into four equal groups, control and SmE-treated for each sex. After the treatment period, an epilepsy model was produced by penicillin G injection (500 IU) into the motor cortex; the electrocorticogram (EcoG) was recorded for 120 min, and statistical analysis was performed. In the male control group with penicillin-induced epilepsy, the spike frequency was significantly (P < 0.05) higher than that in the female control group. The frequency values have been significantly (P < 0.01) increased within the observation period in the female SmE-treated group, while the respective values significantly (P < 0.05) decreased in the analogous male group. There were insignificant differences in the amplitude values and latency to onset of the spike/wave events between female/male SmE and female/male control groups (P > 0.05). Thus, the SmE exerts anticonvulsant effects in the male rat group, while its effect should be characterized as proconvulsant in the female group in the penicillin-induced epilepsy model. The difference (related to the presence of estrogen analogs in the SmE) is determined by dissimilar hormonal backgrounds in males and females. The SmE may be considered as the base for development of anticonvulsant drugs for clinical therapy of epilepsy in the future.en_US
dc.identifier.doi10.1007/s11062-015-9524-zen_US
dc.identifier.endpage224en_US
dc.identifier.issn0090-2977
dc.identifier.issn1573-9007
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage218en_US
dc.identifier.urihttps://doi.org/10.1007/s11062-015-9524-z
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5796
dc.identifier.volume47en_US
dc.identifier.wosWOS:000361988900008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNeurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSalvia miltiorrhizaen_US
dc.subjectelectrocorticographyen_US
dc.subjectpenicillin-induced epileptiform activityen_US
dc.subjectratsen_US
dc.titleEffects of an Extract of Salvia Miltiorrhiza on a Penicillin-Induced Epilepsy Model in Ratsen_US
dc.typeArticleen_US

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