STAT3, VEGF, and PSMA Expression Patterns in Malignant Peripheral Nerve Sheath Tumors, Malignant Melanomas, and Glioblastomas: Does Staining Percentage and Intensity Have an Effect on Survival?

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dc.authorwosidCoşkun, Sinem/AIB-8540-2022
dc.contributor.authorCoşkun, Sinem Kantarcıoğlu
dc.contributor.authorGamsızkan, Mehmet
dc.contributor.authorYalcinkaya, Ulviye
dc.contributor.authorSungur, Mehmet Ali
dc.date.accessioned2023-07-26T11:54:42Z
dc.date.available2023-07-26T11:54:42Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.description.abstractMalignant peripheral nerve sheath tumors (MPNSTs), glioblastomas (GBMs), and malignant melanomas (MMs) are neural crest-originating aggressive tumors with a poor prognosis. Signal transducer and transcription activator 3 (STAT3) plays a role in many biological processes, including cell life and proliferation, the acute phase response, chronic inflammation, autoimmunity, metabolism, and cancer progression, It is also known to be a prooncogenic transcription factor. Vascular endothelial growth factor (VEGF) is one of the most potent proangiogenic stimuli ever identified. It mediates tumor neovascularization, and is associated with angiogenesis and lymphangiogenesis. The prostate-specific membrane antigen (PSMA) folate hydrolase I, despite its name, has been found in tissues other than the prostate. It is overexpressed in prostate cancer cells and several other cancers, and has the potential to be a target for radioligand therapy. We investigated the value of STAT3, VEGF and PSMA immunohistochemical expression patterns and their effects on survival in MPNSTs, GBMs, and MMs. Their expression patterns were evaluated in 25 MPNSTs, 27 GBMs, and 25 MM cases. All GBM cases stained positively for STAT3 and VEGF. In the other groups, the staining patterns were heterogeneous. None of the cases showed positive staining with PSMA. There was no statistically significant difference in survival between cases with differing VEGF and STAT3 staining patterns in the MPSNT and MM groups, but there was an increase in mortality as the VEGF score increased in the GBM group. The suppression of VEGF and STAT3 may be a promising avenue for treatment of MPNSTs, GBMs, and MMs, although further research is needed.en_US
dc.description.sponsorshipBAP unit (Scientific Research Projects) of Duzce Universityen_US
dc.description.sponsorshipThis study was supported financially by the BAP unit (Scientific Research Projects) of Duzce University.en_US
dc.identifier.endpage53en_US
dc.identifier.issn0731-8898
dc.identifier.issn2162-6537
dc.identifier.issue1en_US
dc.identifier.pmid35378003en_US
dc.identifier.scopus2-s2.0-85127479572en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage45en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12902
dc.identifier.volume41en_US
dc.identifier.wosWOS:000770232800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorCoşkun, Sinem Kantarcıoğlu
dc.institutionauthorGamsızkan, Mehmet
dc.institutionauthorSungur, Mehmet Ali
dc.language.isoenen_US
dc.publisherBegell House Incen_US
dc.relation.ispartofJournal of Environmental Pathology Toxicology and Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectVegf; Stat3; Psma; Malignant Peripheral Nerve Sheath Tumor; Malignant Melanoma; Glioblastomaen_US
dc.subjectEndothelial Growth-Factor; Signal Transducer; Angiogenesis; Activation; Pathwayen_US
dc.titleSTAT3, VEGF, and PSMA Expression Patterns in Malignant Peripheral Nerve Sheath Tumors, Malignant Melanomas, and Glioblastomas: Does Staining Percentage and Intensity Have an Effect on Survival?en_US
dc.typeArticleen_US

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