The Effect of Radioactive Iodine Treatment on C-14 Urea Breath Test Results in Patients with Hyperthyroidism

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dc.contributor.authorArduç, Ayşe
dc.contributor.authorDoğan, Bercem Aycicek
dc.contributor.authorÖzuğuz, Ufuk
dc.contributor.authorTuna, Mazhar Müslim
dc.contributor.authorGökay, Ferhat
dc.contributor.authorTütüncü, Yasemin Ateş
dc.contributor.authorGüler, Serdar
dc.date.accessioned2020-04-30T23:33:07Z
dc.date.available2020-04-30T23:33:07Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000345157400002en_US
dc.descriptionPubMed: 25036019en_US
dc.description.abstractPurpose: Radioactive (131)Iodine therapy (RAIT) plays a major role in the treatment of hyperthyroidism. In addition to the thyroid gland, significant amounts of radioactive iodine are maintained in the stomach. The aim of this study was to determine if RAIT has any effect on Helicobacter pylori infection, based on the C-14 urea breath test (UBT). Materials and Methods: The study included 85 patients with hyperthyroidism scheduled to undergo RAIT and 69 hyperthyroid subjects in whom methimazole treatment was planned. All subjects had pretreatment-positive UBT results, and the test was repeated on the first and third months after RAIT and methimazole treatment. Results: After a mean RAIT dose of 15 mCi (range, 10-20 mCi), UBT became negative in 13 (15.3%) of 85 patients on the first month and 18 (21.2%) of 85 patients on the third month. All subjects treated with methimazole remained UBT positive on the first and third months of methimazole treatment (100%). Reduction in the number of UBT-positive patients on both the first and the third months after RAIT was statistically significant (P < 0.001). Distribution of hyperthyroidism etiologies and thyroid autoantibody levels in subjects with UBT that became negative and in subjects with UBT that remained positive were similar in the RAIT group (P > 0.05). Urea breath test negativity rates did not differ according to the radioiodine dose. Conclusions: Our findings indirectly showed that RAIT might have an antimicrobial effect on H. pylori. Clinical applications of this beneficial effect of RAIT on H. pylori should be further evaluated.en_US
dc.identifier.doi10.1097/RLU.0000000000000519en_US
dc.identifier.endpage1026en_US
dc.identifier.issn0363-9762
dc.identifier.issn1536-0229
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1022en_US
dc.identifier.urihttps://doi.org/10.1097/RLU.0000000000000519
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4900
dc.identifier.volume39en_US
dc.identifier.wosWOS:000345157400002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofClinical Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectradioactive iodine therapyen_US
dc.subjecthyperthyroidismen_US
dc.subjectHelicobacter pylorien_US
dc.subjectC-14 urea breath testen_US
dc.titleThe Effect of Radioactive Iodine Treatment on C-14 Urea Breath Test Results in Patients with Hyperthyroidismen_US
dc.typeArticleen_US

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