The relationship between serum leptin level and disease activity and inflammatory markers in fibromyalgia patients

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dc.contributor.authorAtaoğlu, Safinaz
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorSamancı, Rümeysa
dc.contributor.authorÖzşahin, Mustafa
dc.contributor.authorAdmış, Özlem
dc.date.accessioned2020-04-30T23:34:19Z
dc.date.available2020-04-30T23:34:19Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionAnkarali, Handan Camdeviren/0000-0002-3613-0523en_US
dc.descriptionWOS: 000434665900003en_US
dc.descriptionPubMed: 30374474en_US
dc.description.abstractOBJECTIVE: The aim of this study was to investigate whether there is a correlation between serum leptin level, disease activity and inflammation markers in patients with fibromyalgia syndrome (FMS). METHODS: A total of 48 patients with FMS diagnosed according to the 1990 American College of Rheumatology criteria were included in the study, as well as 36 healthy women as controls. The Visual Analogue Scale was used to gauge pain severity, the Fibromyalgia Impact Questionnaire was used to assess physical function, the 36-Item Short Form Health Survey was used to examine quality of life, and depression was measured with the Beck Depression Inventory. Blood samples were examined for erythrocyte sedimentation rate (ESR), C-reactive protein level (CRP), high-sensitivity CRP level (hsCRP), the neutrophil-tolymphocyte ratio (NLR), and the serum leptin level was determined using the enzyme-linked immunosorbent assay method. RESULTS: The serum leptin level in patients with FMS was significantly higher than in the healthy group. However, no significant relationship was found between leptin level and clinical and inflammatory parameters. In addition, there were no significant differences between the patients and the control group in measurements of ESR, CRP, hsCRP, or NLR. CONCLUSION: A higher serum leptin level in patients with FMS suggested that leptin may play role in the pathogenesis of FMS, yet there was no relationship between leptin and clinical and inflammatory parameters, suggesting that leptin is not an indicator of disease activity in FMS. Additional research should be performed with larger patient groups.en_US
dc.identifier.doi10.14744/nci.2017.31644en_US
dc.identifier.endpage108en_US
dc.identifier.issn2148-4902
dc.identifier.issue2en_US
dc.identifier.startpage102en_US
dc.identifier.urihttps://doi.org/10.14744/nci.2017.31644
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5141
dc.identifier.volume5en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofNorthern Clinics Of Istanbulen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFatigue syndromeen_US
dc.subjectfibromyalgiaen_US
dc.subjectinflammationen_US
dc.subjectleptinen_US
dc.titleThe relationship between serum leptin level and disease activity and inflammatory markers in fibromyalgia patientsen_US
dc.typeArticleen_US

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