Comparison of Serum CA 19.9, CA 125 and CEA Levels with Severity of Chronic Obstructive Pulmonary Disease

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dc.contributor.authorBulut, İsmet
dc.contributor.authorArbak, Peri Meram
dc.contributor.authorCoşkun, Abdurrahman
dc.contributor.authorBalbay, Öner Abidin
dc.contributor.authorAnnakkaya, Ali Nihat
dc.contributor.authorYavuz, Özlem
dc.contributor.authorGülcan, Erim
dc.date.accessioned2020-04-30T22:41:25Z
dc.date.available2020-04-30T22:41:25Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionCoskun, Abdurrahman/0000-0002-1273-0604; Annakkaya, Ali Nihat N/0000-0002-7661-8830en_US
dc.descriptionWOS: 000266882200007en_US
dc.descriptionPubMed: 19494536en_US
dc.description.abstractObjective: To investigate serum levels of CA 19.9, CA 125 and carcinoembryonic antigen (CEA) in patients with different stages of chronic obstructive pulmonary disease (COPD). Patients and Methods: Fifty-three consecutive patients (50 males, 3 females, mean age 67.6 +/- 10.1 years) with COPD were included in this study. Serum levels of CA 19.9, CA 25 and CEA were determined by the chemiluminescent immunometric method. Based on values obtained from pulmonary function tests, the patients were divided into 3 groups: moderate (21), severe (18) and very severe (14). Data were analyzed with a Kruskal-Wallis one-way analysis of variance test and Mann-Whitney U test. Results: The mean serum levels of CA 125 and CA 19.9 were significantly higher in patients with very severe COPD (p = 0.013 and p = 0.017, respectively) than in patients with severe and moderate COPD (p < 0.05). Patients with cor pulmonale had significantly high mean serum levels of CEA, CA 19.9 and CA 125 (p < 0.05). Patients using a long-acting beta-agonist and theophylline showed significantly higher mean serum levels of CA 125 than patients who were not (p < 0.05). Conclusion: Data showed that the increased serum tumor markers in patients with COPD might be due to the severity of COPD, medication and cor pulmonale. Copyright (c) 2009 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000215726en_US
dc.identifier.endpage293en_US
dc.identifier.issn1011-7571
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage289en_US
dc.identifier.urihttps://doi.org/10.1159/000215726
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3182
dc.identifier.volume18en_US
dc.identifier.wosWOS:000266882200007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofMedical Principles And Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectTumor markersen_US
dc.subjectCor pulmonaleen_US
dc.titleComparison of Serum CA 19.9, CA 125 and CEA Levels with Severity of Chronic Obstructive Pulmonary Diseaseen_US
dc.typeArticleen_US

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