Evolutionary changes of noncoding elements associated with transition of sexual mode in Caenorhabditis nematodes

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dc.authoridSugimoto, Asako/0000-0001-6001-4293
dc.authoridDAYI, Mehmet/0000-0002-5367-918X
dc.authoridKikuchi, Taisei/0000-0003-2759-9167
dc.authoridMakino, Takashi/0000-0003-4600-9353
dc.authoridTamagawa, Katsunori/0000-0002-8796-6486
dc.authoridSun, Simo/0000-0003-0481-0468;
dc.contributor.authorTamagawa, Katsunori
dc.contributor.authorDayi, Mehmet
dc.contributor.authorSun, Simo
dc.contributor.authorHata, Rikako
dc.contributor.authorKikuchi, Taisei
dc.contributor.authorHaruta, Nami
dc.contributor.authorSugimoto, Asako
dc.date.accessioned2025-10-11T20:48:12Z
dc.date.available2025-10-11T20:48:12Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThe transition of the sexual mode occurs widely in animal evolution. In Caenorhabditis nematodes, androdioecy, a sexual polymorphism composed of males and hermaphrodites having the ability to self-fertilize, has evolved independently multiple times. While the modification of noncoding regulatory elements likely contributed to the evolution of hermaphroditism, little is known about these changes. Here, we conducted a genome-wide analysis of conserved noncoding elements (CNEs) focusing on the evolution of hermaphroditism in Caenorhabditis nematodes. We found that, in androdioecious nematodes, mutations rapidly accumulated in CNEs' neighboring genes associated with sexual traits. Expression analysis indicate that the identified CNEs are involved in spermatogenesis in hermaphrodites and associated with the transition of gene expression from dioecious to androdioecious nematodes. Last, genome editing of a CNE neighboring laf-1 resulted in a change in its expression in the gonadal region undergoing spermatogenesis. Our bioinformatic and experimental analyses highlight the importance of CNEs in gene regulation associated with the development of hermaphrodites.en_US
dc.description.sponsorshipJST, cReST, Japan [JPMJcR18S7]en_US
dc.description.sponsorshipThis work has been supported by JST, cReST grant number JPMJcR18S7, Japan.en_US
dc.identifier.doi10.1126/sciadv.adn9913
dc.identifier.issn2375-2548
dc.identifier.issue37en_US
dc.identifier.pmid39270031en_US
dc.identifier.scopus2-s2.0-85204167530en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1126/sciadv.adn9913
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21804
dc.identifier.volume10en_US
dc.identifier.wosWOS:001313229700005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Assoc Advancement Scienceen_US
dc.relation.ispartofScience Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.titleEvolutionary changes of noncoding elements associated with transition of sexual mode in Caenorhabditis nematodesen_US
dc.typeArticleen_US

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