Introduction of a novel quantitative scoring system for acanthosis nigricans and its validation in a pilot study

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dc.authoridUstunbas Uzuncakmak, Tugba Kevser/0000-0001-8057-3463
dc.authoridWollina, Uwe/0000-0001-5933-2913
dc.authorwosidUzuncakmak, Tugba Kevser Ustunbas/AAH-4236-2021
dc.contributor.authorKaradag, Ayse Serap
dc.contributor.authorUzuncakmak, Tugba Kevser
dc.contributor.authorOzlu, Emin
dc.contributor.authorTakir, Mumtaz
dc.contributor.authorKaradag, Remzi
dc.contributor.authorKostek, Osman
dc.contributor.authorChen, WenChieh
dc.date.accessioned2021-12-01T18:50:56Z
dc.date.available2021-12-01T18:50:56Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractInconsistent data exist regarding the diagnostic value of acanthosis nigricans (AN) or skin tags as clinical markers for obesity or diabetes. In an outpatient department-based prospective study, we designed a scoring for AN severity (SCANS) to evaluate AN and skin tags, their correlation with obesity or diabetes. Quantification of AN in six anatomic sites, in consideration of the affected skin surface areas, texture changes, number of skin tags, leads to a total severity score between 0 and 46. Among 336 adult patients (aged >= 18 years) with AN, a higher BMI was associated with AN (r = 0.299, P < .001), but not with diabetes (P = .43), as compared with 243 age- and sex-matched controls without AN. Among nondiabetics, AN scores were significantly correlated with waist circumference (r = 0.131, P = .024) and total cholesterol levels (r = 0.155, P = .04). Skin tags alone in the absence of AN were not associated with obesity (P = .333) or diabetes (P = .164). The total AN scores were positively correlated with the presence of skin tags (r = 0.132, P < .001), and the involvement of anterior neck (r = 0.668, P < .001) and axilla (r = 0.793, P < .001). Knuckles and groins were unaffected in our series. Our results indicate that combination of AN with skin tags can be used as clinical marker for obesity, but not for diabetes. Large-scale studies on patients of different ethnic background are required to further validate our proposed scoring.en_US
dc.identifier.doi10.1111/dth.14450
dc.identifier.issn1396-0296
dc.identifier.issn1529-8019
dc.identifier.issue6en_US
dc.identifier.pmid33103332en_US
dc.identifier.scopus2-s2.0-85096708449en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/dth.14450
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10946
dc.identifier.volume33en_US
dc.identifier.wosWOS:000586721100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDermatologic Therapyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacanthosis nigricansen_US
dc.subjectbody mass indexen_US
dc.subjectdiabetes mellitusen_US
dc.subjectinsulin resistanceen_US
dc.subjectDiabetes Risk-Factorsen_US
dc.subjectMultiple Skin Tagsen_US
dc.subjectInsulin-Resistanceen_US
dc.subjectPrevalenceen_US
dc.subjectAssociationen_US
dc.subjectHyperpigmentationen_US
dc.subjectCommunityen_US
dc.subjectAmericanen_US
dc.titleIntroduction of a novel quantitative scoring system for acanthosis nigricans and its validation in a pilot studyen_US
dc.typeEditorialen_US

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