WHAT DO PEOPLE PREFER TO SUPPORT DIABETES TREATMENT IN TURKIYE? A STUDY ON OLIVE LEAF AND DIABETES

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dc.authorscopusid58494104000en_US
dc.authorscopusid23570520200en_US
dc.contributor.authorMancak, M.
dc.contributor.authorCaliskan, U.K.
dc.date.accessioned2024-08-23T16:07:28Z
dc.date.available2024-08-23T16:07:28Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: A questionnaire study was conducted to evaluate the applications of plants and herbal products consumed by diabetic patients for the treatment of chronic health conditions. Evaluation of the questionnaire confirmed that olive leaf is one of the most used herbs in the treatment of diabetes, in line with its traditional use in the literature. In vitro biological activity studies were performed to determine whether different olive leaf samples have antidiabetic effects. Additionally, the major component oleuropein was quantitively determined in the samples. Material and Method: The established survey was firstly approved by the ethics committee at Gazi University then the survey was conducted at the University Hospital, Department of Endocrinology between January 2021, and July 2021. Based on the result of the survey, pharmacognostic analyses, chromatographic analyses, and inhibition on diabetes-related enzymes (?-amylase, ?-glucosidase, and aldose reductase) were performed on the samples of olive leaves collected from nature, obtained from herbalists, markets and pharmacies. Result and Discussion: Evaluation of the survey revealed that the patients mostly used cinnamon (29.3%) and olive leaves (21.7%) for the treatment of diabetes, and these plants were generally obtained from herbalists (51.7%). The study findings showed that aqueous and ethanolic extracts prepared from olive leaf samples contained 190.3-374.3 mg/g oleuropein. The amount of oleuropein in the ready-made olive leaf extract from herbalists was found to be much lower (50.9 mg/g) than the other olive leaf extracts. When the enzyme inhibition activity assays were evaluated, it was determined that all olive leaf samples had inhibitory effects on ?-amylase, ?-glucosidase, and aldose reductase enzymes. All olive leaf samples, including teas prepared by the public at home with water, were found to have capacity to decrease the blood level in other words antidiabetic activities in vitro. The oleuropein contents detected in this study once again revealed the importance of meticulous examination in herbal products. © 2024 University of Ankara. All rights reserved.en_US
dc.identifier.doi10.33483/jfpau.1378992
dc.identifier.endpage455en_US
dc.identifier.issn2564-6524
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85195856279en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage436en_US
dc.identifier.trdizinid1236417en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.1378992
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1236417
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14650
dc.identifier.volume48en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAldose reductaseen_US
dc.subjecthigh pressure liquid chromatographyen_US
dc.subjectOlea europeaen_US
dc.subject?-amylaseen_US
dc.subject?-glucosidaseen_US
dc.subjectacarboseen_US
dc.subjectalcoholen_US
dc.subjectaldehyde reductaseen_US
dc.subjectaldose reductase inhibitoren_US
dc.subjectaloe vera gelen_US
dc.subjectalpha glucosidaseen_US
dc.subjectalpha glucosidase inhibitoren_US
dc.subjectamylaseen_US
dc.subjectamylase inhibitoren_US
dc.subjectantidiabetic agenten_US
dc.subjectcoconut oilen_US
dc.subjectglucoseen_US
dc.subjectherbaceous agenten_US
dc.subjectinsulinen_US
dc.subjectOlea europaea extracten_US
dc.subjectoleuropeinen_US
dc.subjectolive oilen_US
dc.subjectoral antidiabetic agenten_US
dc.subjectplant extracten_US
dc.subjectquercetinen_US
dc.subjectrosemary oilen_US
dc.subjectst john wort oilen_US
dc.subjectunclassified drugen_US
dc.subjectvegetable oilen_US
dc.subjectwound healing promoting agenten_US
dc.subjectadulten_US
dc.subjectantidiabetic activityen_US
dc.subjectaqueous solutionen_US
dc.subjectArticleen_US
dc.subjectblack cuminen_US
dc.subjectblueberryen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectcerebrovascular diseaseen_US
dc.subjectchronic diseaseen_US
dc.subjectcinnamonen_US
dc.subjectcontrolled studyen_US
dc.subjectcross-sectional studyen_US
dc.subjectdescriptive researchen_US
dc.subjectdiabetes mellitusen_US
dc.subjectdiabetic footen_US
dc.subjectdiabetic heart diseaseen_US
dc.subjectdiabetic nephropathyen_US
dc.subjectdiabetic neuropathyen_US
dc.subjectdiabetic patienten_US
dc.subjectdiabetic retinopathyen_US
dc.subjectdiabetic wounden_US
dc.subjectdrug determinationen_US
dc.subjectenzyme inhibitionen_US
dc.subjectethnopharmacologyen_US
dc.subjectfemaleen_US
dc.subjectfenugreeken_US
dc.subjectgarlicen_US
dc.subjectginsengen_US
dc.subjectglucose blood levelen_US
dc.subjectglycemic controlen_US
dc.subjectherben_US
dc.subjectherbal medicineen_US
dc.subjectherbal teaen_US
dc.subjecthigh performance liquid chromatographyen_US
dc.subjecthumanen_US
dc.subjectin vitro studyen_US
dc.subjectinsulin treatmenten_US
dc.subjectliver diseaseen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectmarketen_US
dc.subjectmiddle ageden_US
dc.subjectMomordica charantiaen_US
dc.subjectolive treeen_US
dc.subjectperipheral vascular diseaseen_US
dc.subjectpharmacognosyen_US
dc.subjectpharmacy (shop)en_US
dc.subjectplant leafen_US
dc.subjectquantitative analysisen_US
dc.subjectquestionnaireen_US
dc.subjectthin layer chromatographyen_US
dc.subjecttraditional healeren_US
dc.subjectTurkey (republic)en_US
dc.subjectuniversity hospitalen_US
dc.subjectwound healingen_US
dc.titleWHAT DO PEOPLE PREFER TO SUPPORT DIABETES TREATMENT IN TURKIYE? A STUDY ON OLIVE LEAF AND DIABETESen_US
dc.typeArticleen_US

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