WHAT DO PEOPLE PREFER TO SUPPORT DIABETES TREATMENT IN TURKIYE? A STUDY ON OLIVE LEAF AND DIABETES
Yükleniyor...
Dosyalar
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
University of Ankara
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: A questionnaire study was conducted to evaluate the applications of plants and herbal products consumed by diabetic patients for the treatment of chronic health conditions. Evaluation of the questionnaire confirmed that olive leaf is one of the most used herbs in the treatment of diabetes, in line with its traditional use in the literature. In vitro biological activity studies were performed to determine whether different olive leaf samples have antidiabetic effects. Additionally, the major component oleuropein was quantitively determined in the samples. Material and Method: The established survey was firstly approved by the ethics committee at Gazi University then the survey was conducted at the University Hospital, Department of Endocrinology between January 2021, and July 2021. Based on the result of the survey, pharmacognostic analyses, chromatographic analyses, and inhibition on diabetes-related enzymes (?-amylase, ?-glucosidase, and aldose reductase) were performed on the samples of olive leaves collected from nature, obtained from herbalists, markets and pharmacies. Result and Discussion: Evaluation of the survey revealed that the patients mostly used cinnamon (29.3%) and olive leaves (21.7%) for the treatment of diabetes, and these plants were generally obtained from herbalists (51.7%). The study findings showed that aqueous and ethanolic extracts prepared from olive leaf samples contained 190.3-374.3 mg/g oleuropein. The amount of oleuropein in the ready-made olive leaf extract from herbalists was found to be much lower (50.9 mg/g) than the other olive leaf extracts. When the enzyme inhibition activity assays were evaluated, it was determined that all olive leaf samples had inhibitory effects on ?-amylase, ?-glucosidase, and aldose reductase enzymes. All olive leaf samples, including teas prepared by the public at home with water, were found to have capacity to decrease the blood level in other words antidiabetic activities in vitro. The oleuropein contents detected in this study once again revealed the importance of meticulous examination in herbal products. © 2024 University of Ankara. All rights reserved.
Açıklama
Anahtar Kelimeler
Aldose reductase, high pressure liquid chromatography, Olea europea, ?-amylase, ?-glucosidase, acarbose, alcohol, aldehyde reductase, aldose reductase inhibitor, aloe vera gel, alpha glucosidase, alpha glucosidase inhibitor, amylase, amylase inhibitor, antidiabetic agent, coconut oil, glucose, herbaceous agent, insulin, Olea europaea extract, oleuropein, olive oil, oral antidiabetic agent, plant extract, quercetin, rosemary oil, st john wort oil, unclassified drug, vegetable oil, wound healing promoting agent, adult, antidiabetic activity, aqueous solution, Article, black cumin, blueberry, cardiovascular disease, cerebrovascular disease, chronic disease, cinnamon, controlled study, cross-sectional study, descriptive research, diabetes mellitus, diabetic foot, diabetic heart disease, diabetic nephropathy, diabetic neuropathy, diabetic patient, diabetic retinopathy, diabetic wound, drug determination, enzyme inhibition, ethnopharmacology, female, fenugreek, garlic, ginseng, glucose blood level, glycemic control, herb, herbal medicine, herbal tea, high performance liquid chromatography, human, in vitro study, insulin treatment, liver disease, major clinical study, male, market, middle aged, Momordica charantia, olive tree, peripheral vascular disease, pharmacognosy, pharmacy (shop), plant leaf, quantitative analysis, questionnaire, thin layer chromatography, traditional healer, Turkey (republic), university hospital, wound healing
Kaynak
Ankara Universitesi Eczacilik Fakultesi Dergisi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
48
Sayı
2
