The effectiveness of blood routine parameters and some biomarkers as a potential diagnostic tool in the diagnosis and prognosis of Covid-19 disease

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dc.authoridILKBAHAR, FATIH/0000-0002-7964-3433
dc.contributor.authorHuyut, Mehmet Tahir
dc.contributor.authorIlkbahar, Fatih
dc.date.accessioned2021-12-01T18:48:40Z
dc.date.available2021-12-01T18:48:40Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractSince February-2020, the world has been battling a tragic public-health crisis with the emergence and spread of 2019-nCoV. Due to the lack of information about the pathogenesis-specific treatment of Covid-19, early diagnosis and timely treatment are important. However, there is still a lack of information about routine-blood-parameteres (RBP) findings and effects in the disease process. Although the literature includes various interventions, existing studies need to be generalized and their reliability improved. In this study, the efficacy of routine blood values used in the diagnosis and prognosis of Covid-19 and independent biomarkers obtained from them were evaluated retrospectively in a large patient group. Low lymphocyte (LYM) and white-blood-cell (WBC), high CRP and Ferritin were effective in the diagnosis of the disease. The (d-CWL) = CRP/WBC*LYM and (d-CFL) = CRP*Ferritin/LYM biomarkers derived from them were the most important risk factors in diagnosing the disease and were more successful than direct RBP values. High d-CWL and d-CFL values largely confirmed the Covid-19 diagnosis. The most effective RBP in the prognosis of the disease was CRP. (d-CIT) = CRP*INR*Troponin; (d-CT) = CRP*Troponin; (d-PPT) = PT*Troponin*Procalcitonin biomarkers were found to be more successful than direct RBP values and biomarkers used in previous studies in the prognosis of the disease. In this study, biomarkers derived from RBP were found to be more successful in both diagnosis and prognosis of Covid-19 than previously used direct RBP and biomarkers.en_US
dc.identifier.doi10.1016/j.intimp.2021.107838
dc.identifier.issn1567-5769
dc.identifier.issn1878-1705
dc.identifier.pmid34303274en_US
dc.identifier.scopus2-s2.0-85110620249en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.intimp.2021.107838
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10583
dc.identifier.volume98en_US
dc.identifier.wosWOS:000687391400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Immunopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCovid-19en_US
dc.subjectBiochemical, hematological and inflammatory biomarkersen_US
dc.subjectBlood routine parametersen_US
dc.subjectCovid-19's independent biomarkersen_US
dc.subjectAbnormalitiesen_US
dc.subjectPredictorsen_US
dc.titleThe effectiveness of blood routine parameters and some biomarkers as a potential diagnostic tool in the diagnosis and prognosis of Covid-19 diseaseen_US
dc.typeArticleen_US

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