Mean platelet volume in patients with dipper and non-dipper hypertension

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dc.contributor.authorOrdu, Serkan
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorÇağlar, Onur
dc.contributor.authorAlemdar, Recai
dc.contributor.authorBaşar, Cengiz
dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorErden, İsmail
dc.date.accessioned2020-04-30T23:19:07Z
dc.date.available2020-04-30T23:19:07Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000276866600006en_US
dc.descriptionPubMed: 19929284en_US
dc.description.abstractPatients with non-dipper hypertension are known to carry a high risk of cardiovascular complications. In this study, we hypothesized that non-dippers may be associated with platelet dysfunction and it can be determined by mean platelet volume (MPV). A total of 216 outpatients treated with antihypertensive drugs for at least 6 months were enrolled. Dipper and non-dipper patterns were detected and clinical, laboratory and ambulatory blood pressure recording data were matched between non-dipping and dipping groups. MPV was significantly higher in patients in non-dipping than dipping groups (p < 0.001). In correlation analyses, MPV was negatively correlated with the rate of systolic and diastolic fall at night (p < 0.001, r=-0.46) and (p < 0.001, r=-0.43), respectively. Also MPV was correlated with nocturnal pulse pressure (p=0.001, r=0.22). Other variables were similar between non-dipping and dipping groups. The present study showed that MPV is higher in non-dipping than dipping hypertensive patients. Platelet activation or dysfunction probably is an alternative mechanism for increasing cardiovascular events in non-dippers.en_US
dc.identifier.doi10.3109/08037050903416402en_US
dc.identifier.endpage30en_US
dc.identifier.issn1651-1999
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage26en_US
dc.identifier.urihttps://doi.org/10.3109/08037050903416402
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3653
dc.identifier.volume19en_US
dc.identifier.wosWOS:000276866600006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBlood Pressureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDipper and non-dipper hypertensionen_US
dc.subjectmean platelet volumeen_US
dc.subjectplateleten_US
dc.titleMean platelet volume in patients with dipper and non-dipper hypertensionen_US
dc.typeArticleen_US

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