Correlation of perilipin 2 and lipid metabolism in elective cesarean section and vaginal delivery: a prospective study with oxidative and apoptotic pathways

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dc.authoridHacioglu, Ceyhan/0000-0002-0993-6118
dc.contributor.authorHacioglu, Ceyhan
dc.contributor.authorSahin, Ibrahim Ethem
dc.contributor.authorUyuk, Can
dc.date.accessioned2021-12-01T18:47:17Z
dc.date.available2021-12-01T18:47:17Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractVaginal delivery (VD) and elective cesarean (CS) delivery modes may cause significant differences in maternal and fetal metabolism. In this study, we aimed to investigate changes in lipid metabolism, oxidative and apoptotic signaling pathways during VD and CS in maternal and cord blood and placenta tissue. The study included two groups of participants delivered via 90 CS and 90 VD. Maternal and cord blood samples were collected from the participants. In addition, placenta samples were also taken after delivery. Total oxidant (TOS), malondialdehyde (MDA), total antioxidant (TAS), glutathione (GSH), cleaved caspase 3 (CASP3) and perilipin 2 (PLIN2) levels were measured to determine oxidative stress, antioxidant levels and apoptosis status in the VD and CS groups. Besides, PLIN2 mRNA expressions in placental specimens were analyzed. We found no statistically significant difference in maternal age, body mass index, gestational age, birth weight and Apgar scores in both groups (P > 0.05). The increase in MDA, TOS, GSH and TAS levels was higher in the VD group compared to the CS group (P < 0.05). Similarly, PLIN2 levels and lipid profiles showed an increase in the VD group (P < 0.05 vs CS group). Likewise, PLIN2 expression enhanced in the VD group (P < 0.05 vs CS group). However, CASP3 activity reduced in maternal and cord blood in the VD group compared to the CS group. Our results support that the delivery mode may cause differences in lipid profile, oxidative and apoptotic status by affecting PLIN2 levels in both maternal and cord blood and placenta tissue.en_US
dc.identifier.doi10.1007/s11033-021-06399-6
dc.identifier.endpage3998en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue5en_US
dc.identifier.pmid34009567en_US
dc.identifier.scopus2-s2.0-85106280968en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3991en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-021-06399-6
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10220
dc.identifier.volume48en_US
dc.identifier.wosWOS:000652085200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectElective cesareanen_US
dc.subjectLipit profileen_US
dc.subjectOxidative stressen_US
dc.subjectPerilipin 2en_US
dc.subjectVaginal deliveryen_US
dc.subjectCord Blooden_US
dc.subjectStressen_US
dc.subjectBirthen_US
dc.subjectModeen_US
dc.subjectBiomarkersen_US
dc.subjectLaboren_US
dc.subjectGshen_US
dc.titleCorrelation of perilipin 2 and lipid metabolism in elective cesarean section and vaginal delivery: a prospective study with oxidative and apoptotic pathwaysen_US
dc.typeArticleen_US

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