Evaluation of left ventricular systolic asynchrony in patients with subclinical hypothyroidism

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dc.contributor.authorÖztürk, Serkan
dc.contributor.authorAlçelik, Aytekin
dc.contributor.authorÖzyaşar, Mehmet
dc.contributor.authorDikbaş, Oğuz
dc.contributor.authorAyhan, Selim
dc.contributor.authorÖzlü, Fatih
dc.contributor.authorYazıcı, Mehmet
dc.date.accessioned2020-05-01T12:15:32Z
dc.date.available2020-05-01T12:15:32Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionAlcelik, Aytekin/0000-0002-3156-1076en_US
dc.descriptionWOS: 000309036000007en_US
dc.descriptionPubMed: 22825898en_US
dc.description.abstractBackground: The heart was very sensitive to fluctuating thyroid hormone levels. To assess intra-left ventricular (LV) systolic asynchrony in patients with subclinical thyroid dysfunction. Methods: Fifty patients with subclinical hypothyroidism and 40 controls were included. A diagnosis of subclinical hypothyroidism was reached with increased TSH and normal free T4. All subjects were evaluated by echocardiography. Evaluation of intra-LV systolic asynchrony was performed by tissue synchronization imaging (TSI), and four TSI parameters of systolic asynchrony were calculated. LV asynchrony was defined by these parameters. Results: All of the groups were similar in terms of demographic findings and conventional and Doppler echocardiograpic parameters except peak systolic velocity and early diastolic velocity. LV systolic asynchrony parameters of TSI including; standard deviation of Ts of the 12 LV segments (Ts-SD-12), maximal difference in Ts between any 2 of the 12 LV segments (Ts-12), standard deviation of TS of the 6 basal LV segments (Ts-SD-6), maximal difference in Ts between any of the 6 basal LV segments (Ts-6) were significantly lengthened in patients with subclinical hypothyroidism than controls (p < 0.001, p < 0.001, p < 0.001 and p < 0.001, respectively). The prevalence of LV asynchrony was significantly higher in patients with subclinical hypothyroidism than control. Conclusions: Patients with subclinical hypothyroidism present evidence of LV asynchrony by TSI. LV systolic asynchrony could be a warning sign of the early stage in cardiac systolic dysfunction in subclinical hypothyroid patients. (Cardiol J 2012; 19, 4: 374-380)en_US
dc.identifier.doi10.5603/CJ.2012.0068en_US
dc.identifier.endpage380en_US
dc.identifier.issn1897-5593
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage374en_US
dc.identifier.urihttps://doi.org/10.5603/CJ.2012.0068
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6397
dc.identifier.volume19en_US
dc.identifier.wosWOS:000309036000007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofCardiology Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectleft ventricular asynchronyen_US
dc.subjectthyroid stimulating hormoneen_US
dc.subjecttissue synchronization imagingen_US
dc.titleEvaluation of left ventricular systolic asynchrony in patients with subclinical hypothyroidismen_US
dc.typeArticleen_US

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