Investıgatıon of the effects of treatment with enoxaparın sodıum and hyperbarıc oxygen therapy on the recovery of rats wıth achılles tendon rupture

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dc.authoridUludağ, Veysel/0000-0002-9911-5961en_US
dc.authorscopusid58797175900en_US
dc.authorscopusid23768513300en_US
dc.authorscopusid57209297847en_US
dc.authorscopusid55353048000en_US
dc.authorscopusid57215363582en_US
dc.authorscopusid57212620333en_US
dc.authorscopusid58798542700en_US
dc.authorwosidUludağ, Veysel/ABZ-8655-2022en_US
dc.contributor.authorAytekin, Cafer Erman
dc.contributor.authorTurhan, Yalcin
dc.contributor.authorKaraduman, Zekeriya Okan
dc.contributor.authorArican, Mehmet
dc.contributor.authorSaglam, Sonmez
dc.contributor.authorCoskun, Sinem Kantarcioglu
dc.contributor.authorUludag, Veysel
dc.date.accessioned2024-08-23T16:04:06Z
dc.date.available2024-08-23T16:04:06Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractPurpose In this study, we aimed to investigate the effects of hyperbaric oxygen therapy and enoxaparin sodium, which are known to accelerate bone tissue healing as well as tendon and soft tissue healing, on the healing of Achilles tendon rupture. Methods Thirty-six rats were used in the present study. All rats were divided into groups of nine. The groups were the enoxaparin sodium group, enoxaparin sodium and hyperbaric oxygen group, hyperbaric oxygen group and control group. After 21 days, the process was completed, and the rats were sacrificed. Achilles tendon samples were evaluated histopathologically. Results The groups were compared according to the results of statistical analysis based on the histopathological data. There was no significant difference between the groups in terms of acute inflammation (p = 0.785) or chronic inflammation (p = 0.827) scores, but there were significant differences in neovascularization (p = 0.009), proliferation (p < 0.001) and fibrosis (p = 0.006) scores. Conclusion Our study showed that the use of enoxaparin sodium and hyperbaric oxygen had a positive effect on the healing of the Achilles tendon. Based on these results, we believe that the use of enoxaparin sodium and hyperbaric oxygen therapy after Achilles tendon rupture will be beneficial for healing and preventing complications.en_US
dc.description.sponsorshipDAS:The datasets used and/or analyzed during the current study available from the corresponding author on reasonable request.en_US
dc.identifier.doi10.1186/s12891-024-07694-6
dc.identifier.issn1471-2474
dc.identifier.issue1en_US
dc.identifier.pmid39020358en_US
dc.identifier.scopus2-s2.0-85198831235en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1186/s12891-024-07694-6
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14067
dc.identifier.volume25en_US
dc.identifier.wosWOS:001271949300002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofBmc Musculoskeletal Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAchilles tendon ruptureen_US
dc.subjectHyperbaric oxygen therapyen_US
dc.subjectEnoxaparin sodiumen_US
dc.subjectRaten_US
dc.subjectRepairen_US
dc.subjectTendinopathyen_US
dc.subjectRegenerationen_US
dc.subjectHeparinen_US
dc.titleInvestıgatıon of the effects of treatment with enoxaparın sodıum and hyperbarıc oxygen therapy on the recovery of rats wıth achılles tendon ruptureen_US
dc.typeArticleen_US

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