N-Acetyl cysteine and erdosteine treatment in acetaminophen-induced liver damage

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dc.contributor.authorSarıtaş, Ayhan
dc.contributor.authorKandiş, Hayati
dc.contributor.authorBaltacı, Davut
dc.contributor.authorYıldırım, Ümran
dc.contributor.authorKaya, Halil
dc.contributor.authorKarakuş, Ali
dc.contributor.authorKara, İsmail Hamdi
dc.date.accessioned2020-04-30T23:19:27Z
dc.date.available2020-04-30T23:19:27Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionKARA, ISMAIL HAMDI/0000-0003-2022-1882; KARA, ISMAIL HAMDI/0000-0003-2022-1882; karakus, ali/0000-0003-1358-3201; Saritas, Ayhan/0000-0002-4302-1093; Saritas, Ayhan/0000-0002-4302-1093; Kandis, Hayati/0000-0001-9151-6050en_US
dc.descriptionWOS: 000340203500009en_US
dc.descriptionPubMed: 23070635en_US
dc.description.abstractObjective: This study is aimed to investigate the efficacy of erdosteine usage in acetaminophen-induced liver damage and to compare it with N-acetyl cysteine (NAC) in the treatment and prevention of liver toxicity due to overdose of acetaminophen. Methods: The rats were separated into the following six groups of seven rats each: control group; acetaminophen (1 g/kg, orally); acetaminophen (1 g/kg, orally) + erdosteine (150 mg/kg/day, orally); acetaminophen (1 g/kg, orally) + NAC (140 mg/kg loading dose, followed by 70 mg/kg, orally); NAC (140 mg/kg loading dose, followed by 70 mg/kg, orally); erdosteine (150 mg/kg/kg, orally), subsequently. In all the groups, potential liver injuries were evaluated using biochemical and hematological analyses, oxidant-antioxidant parameters and histopathological parameters. Results: In acetaminophen-treated group, levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total oxidant status (TOS) in the blood, prothrombin time (PT) and international normalized ratio (INR) were significantly increased when compared with controls. However, total antioxidant capacity (TAC) and glutathione (GSH) levels were decreased in group treated with acetaminophen, when compared with control group. Levels of AST, ALT and TOS, PT and INR were decreased in groups treated with NAC and erdosteine after acetaminophen administration, but the levels of TAC and GSH were increased. Histopathological improvements were observed in the groups treated with NAC and erdosteine after acetaminophen administration. Conclusion: The present study demonstrated that, in the prevention of liver damage induced by acetaminophen intoxication, an early treatment with a single dose of erdosteine was beneficial instead of NAC administration.en_US
dc.description.sponsorshipEmergency Physicians Association of Turkeyen_US
dc.description.sponsorshipThe authors thank the Emergency Physicians Association of Turkey for the financial support and its valued contribution.en_US
dc.identifier.doi10.1177/0748233712463780en_US
dc.identifier.endpage678en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage670en_US
dc.identifier.urihttps://doi.org/10.1177/0748233712463780
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3761
dc.identifier.volume30en_US
dc.identifier.wosWOS:000340203500009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology And Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLiver toxicityen_US
dc.subjecttotal oxidant statusen_US
dc.subjecttotal antioxidant capacityen_US
dc.subjectpoisoningen_US
dc.subjectparacetamolen_US
dc.titleN-Acetyl cysteine and erdosteine treatment in acetaminophen-induced liver damageen_US
dc.typeArticleen_US

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