Investigation of TLR4 Polymorphism in Children with Vesicoureteral Reflux and Renal Scarring

Basit Öğe Kaydı
dc.contributor.authorSav, Nm
dc.contributor.authorEroz, R.
dc.contributor.authorKalay, Duran N.
dc.contributor.authorKilicaslan, O.
dc.contributor.authorErisen, Karaca S.
dc.date.accessioned2025-10-11T20:47:52Z
dc.date.available2025-10-11T20:47:52Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractVesicoureteral reflux (VUR) is an important factor in the etiology of recurrent urinary tract infections (UTIs). Permanent kidney damage may develop in children with high-grade VUR in the long term. This damage may progress with the development of scar tissue in some patients. The TLR4 gene is an important resistance mechanism, especially against UTIs. TLR4 gene polymorphism is associated with recurrent UTIs and kidney scar development in the long term. This study aimed to examine the relationship between scar development and TLR4 gene polymorphism in children with VUR. This cross-sectional study included 49 patients with recurrent UTIs and primary vesicoureteral reflux. Patients were divided into two groups (26 patients with the scar, and 23 patients without scar) according to the presence of scar tissue. TLR4 gene polymorphisms of the patients were evaluated by Next Generation Sequencing. The TLR4 gene polymorphism was significantly higher in the compound heterozygous group with scarring than in the group without scarring (p=0.03). Gene polymorphisms, c.958T>C, c.942A>G, c.776A>G, c.1076C>T, c.896AT, c.1078C>T were presented more commonly in the group with scarring. Moreover, gene polymorphisms c.942A>G and c.776A>G were defined for the first time in this study among patients with scar tissue. The higher incidence of some TLR4 gene polymorphisms in patients with scarring suggested that these variations might cause permanent kidney damage. In addition to genetic predisposition, environmental factors such as untreated UTIs might also contribute to scar formation.en_US
dc.identifier.doi10.2478/bjmg-2024-0013
dc.identifier.endpage47en_US
dc.identifier.issn1311-0160
dc.identifier.issn2199-5761
dc.identifier.issue2en_US
dc.identifier.pmid40070863en_US
dc.identifier.scopus2-s2.0-105003490261en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage41en_US
dc.identifier.urihttps://doi.org/10.2478/bjmg-2024-0013
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21625
dc.identifier.volume27en_US
dc.identifier.wosWOS:001438729700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSciendoen_US
dc.relation.ispartofBalkan Journal of Medical Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectNext Generation Sequencingen_US
dc.subjectToll-Like Receptor 4en_US
dc.subjectUrinary tract infectionen_US
dc.subjectVesico-ureteral refluxen_US
dc.titleInvestigation of TLR4 Polymorphism in Children with Vesicoureteral Reflux and Renal Scarringen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu