In silico and biological activity evaluation of quercetin-boron hybrid compounds, anti-quorum sensing effect as alternative potential against microbial resistance

Basit Öğe Kaydı
dc.authoridTÜRKMENOĞLU, BURÇİN/0000-0002-5770-0847
dc.authorwosidTÜRKMENOĞLU, BURÇİN/ABG-4951-2020
dc.contributor.authorTemel, Hamdi
dc.contributor.authorAtlan, Metin
dc.contributor.authorTuerkmenoglu, Burgin
dc.contributor.authorErtas, Abdulselam
dc.contributor.authorErdönmez, Demet
dc.contributor.authorÇalışkan, Ufuk Koca
dc.date.accessioned2023-07-26T11:51:14Z
dc.date.available2023-07-26T11:51:14Z
dc.date.issued2023
dc.departmentDÜ, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractBoronic acid compounds and the natural flavonoid compound quercetin were handled to synthesize two novel ligands encoded as B1(2,2 '-(1,4-phenylenebis (benzo [1,3,2] dioxaborole-2,5-diyl)) bis (3,5,7-trihydroxy-4H-chromen-4-one) and B2(3.3.6. 3,5,7-trihydroxy-2-(2-(6-methoxypyridin-3-yl)benzo[d][1,3,2]dioxaborol-5-yl)-4 H-chromene-4). Antioxidant activities of ligands were investigated by DPPH, ABTS and CUPRAC methods. Cholinesterase inhibition effects of ligands were determined by acetylcholinesterase and butyrylcholinesterase enzyme inhibition methods, cytotoxic effects of ligands were applied to healthy breast and colon cancer cell lines by MTT method, and urease and tyrosinase enzyme activities were determined. Antimicrobial properties of the compounds were analyzed by detecting their anti-QS potentials on Chromobacterium violaceum biosensor strain. Both compounds were found to have significant antioxidant effects compared to controls. It was determined that the compound B1 at 1-10 mu g/mL was more active than the reference compounds (alpha-TOC and BHT). Moreover, the enzyme activity studies on ligands demonstrated that acetylchoinesterase and butyrylcholinesterase enzyme inhibitions were higher than the reference compounds. As expected, boron derivatives exhibited respectable activity against the biofilms of Escherichia coli (E. coli) and P. aeruginosa (P. aeruginosa). These results demonstrate the potential applicability of boron derivatives in the treatment of biofilm-associated infections and provide a practical strategy for the design of new boron-based antimicrobial materials. In silico molecular docking studies were performed on ligands to identify newly synthesized compounds. The binding parameter values and binding sites of the compounds were also determined. In conclusion, our studies showed that newly synthesized hybrid compounds could be solutions for antimicrobial resistance and enzyme-related disorders.en_US
dc.description.sponsorshipDicle University Scientific and Technological Research Council (DUBAP) [ECZACILIK.17.003]; Basic Sciences Application and Research Center (EBYU-EUTAM) [2021-2]en_US
dc.description.sponsorshipDicle University Scientific and Technological Research Council (DUBAP) with Grant Number: ECZACILIK.17.003 is gratefully acknowledged for their financial supports. Authors would like to thank Erzincan Binali Yıldırım University, Basic Sciences Application and Research Center (EBYU-EUTAM) for the usage of Schrodinger Maestro 2021-2 program. Authors also would like to thank to Prof. Dr. Barry Thompson (University of Southern California, Dornsife USA) for proofing the manuscript.en_US
dc.identifier.doi10.1016/j.jtemb.2023.127139
dc.identifier.issn0946-672X
dc.identifier.issn1878-3252
dc.identifier.pmid36791625en_US
dc.identifier.scopus2-s2.0-85147950127en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2023.127139
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12520
dc.identifier.volume77en_US
dc.identifier.wosWOS:000947405700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorErdönmez, Demet
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofJournal of Trace Elements In Medicine and Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectBoron; Quercetin; Antioxidant; Antibacterial; Chromobacterium Violaceum; Anti-Quorum Sensing Qs Mtt Method; Molecular Docking Studiesen_US
dc.subjectComplex; Acetylcholinesterase; Tyrosinase; Aciden_US
dc.titleIn silico and biological activity evaluation of quercetin-boron hybrid compounds, anti-quorum sensing effect as alternative potential against microbial resistanceen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
12520.pdf
Boyut:
4.29 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu