Omentin Val/Val genotype increases predisposition to acne vulgaris without changing omentin serum level

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dc.contributor.authorSoğuktaş, Hatice
dc.contributor.authorYaykaşlı, Kürşat Oğuz
dc.contributor.authorTuran, Hakan
dc.contributor.authorKaya, Ertuğrul
dc.contributor.authorYaykaşlı, Emine
dc.date.accessioned2020-04-30T23:19:51Z
dc.date.available2020-04-30T23:19:51Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionYaykasli, Kursat/0000-0001-7550-6370en_US
dc.descriptionWOS: 000449068700016en_US
dc.descriptionPubMed: 30301508en_US
dc.description.abstractAcne vulgaris is the most frequent and multifactorial inflammatory skin disorder in all races. Obesity is considered to be a risk factor for acne due to its contribution to inflammation. The involvements of inflammatory (leptin and resistin) and anti-inflammatory (adiponectin) adipokines in the pathogenesis of acne were reported. Omentin resembles adiponectin in terms of having inhibitory effect on tumor necrosis factor-alpha (TNF-alpha) induced inflammation, a vital process in the acne formation. This study was designed to investigate the putative involvement of omentin in acne formation. The genotyping was performed by restriction fragment length polymorphism (RFLP) method. Serum omentin protein levels were analyzed by enzyme-linked immunosorbent assay (ELISA). Serum omentin level was not significantly changed between groups. However, the decreased serum omentin level was observed as the mean value of BMI increased. The Asp/Asp, Val/Asp and Val/Val genotypes distributions for control and patient groups (19[17.4%], 22[20.2%], and 3[2.8%] respectively, vs. 31[28.4%], 25[22.9%], and 9[8.3%], respectively) were obtained. The Val/Val (mutant homozygote) genotype was found nearly 1.8 times more in the patient group (p=0.403, OR=1.839 (0.442-7.653)). This is the first time to clarify a linkage between anti-inflammatory omentin and acne vulgaris. Omentin Val109Asp polymorphism affects the overall function of the protein. In conclusion, omentin Val/Val (mutant homozygote) genotype increases predisposition to acne vulgaris by probably disrupting overall protein function of omentin.en_US
dc.description.sponsorshipDuzce University Research FundDuzce University [2012.04.HD.043]en_US
dc.description.sponsorshipThis project is supported by Duzce University Research Fund, Project Number 2012.04.HD.043en_US
dc.identifier.doi10.14715/cmb/2018.64.12.16en_US
dc.identifier.endpage86en_US
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://doi.org/10.14715/cmb/2018.64.12.16
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3868
dc.identifier.volume64en_US
dc.identifier.wosWOS:000449068700016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherC M B Assocen_US
dc.relation.ispartofCellular And Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOmentinen_US
dc.subjectAcne vulgarisen_US
dc.subjectInflammationen_US
dc.subjectObesityen_US
dc.subjectAdipokinesen_US
dc.titleOmentin Val/Val genotype increases predisposition to acne vulgaris without changing omentin serum levelen_US
dc.typeArticleen_US

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