Evaluation of angiogenic apelin/apelin receptor axis in normal prostate, high grade prostatic intraepithelial neoplasia and prostatic adenocarcinoma

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dc.authorscopusid55982152000
dc.authorscopusid55925600400
dc.authorscopusid57223843443
dc.authorscopusid57162951400
dc.authorscopusid57224497171
dc.authorscopusid6602989907
dc.contributor.authorSoylu, Hakan
dc.contributor.authorÜnal, B.
dc.contributor.authorAksu, K.
dc.contributor.authorAvci, S.
dc.contributor.authorCaylan, A.E.
dc.contributor.authorÜstünel, İ.
dc.date.accessioned2023-07-26T11:51:31Z
dc.date.available2023-07-26T11:51:31Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractIntroduction and Objectives: Prostate cancer is one of the most commonly diagnosed cancers in American men. Apelin is an endogenous peptide identified as the ligand of the G protein-associated apelin receptor. Apelin and apelin receptor have many tissues distribution and they participate in pathological processes, such as cancer. Apelin stimulates cancer angiogenesis. However, there are insufficient data in the literature regarding the role of apelin/apelin receptor in normal tissue, high-grade prostatic intraepithelial neoplasia, and prostatic adenocarcinoma tissues. Therefore, this study aimed to investigate the apelin and apelin receptor expression levels in tissues of normal prostate tissue, high-grade prostatic intraepithelial neoplasia, and prostatic adenocarcinoma. Materials and Methods: In this study, 38 samples of patients undergoing radical prostatectomy were used. Among 38 samples; 20 patients were with prostatic adenocarcinoma, 18 patients were with high-grade prostatic intraepithelial neoplasia and adjacent normal prostatic tissue areas. The immunolocalisation of apelin and apelin receptor in these tissues were determined immunohistochemically. Results: Apelin and apelin receptor expressions were higher in prostatic adenocarcinoma than normal prostate tissue and high-grade prostatic intraepithelial neoplasia. Apelin receptor expression was also increased in high-grade prostatic intraepithelial neoplasia compared to normal tissue. Conclusion: Apelin and apelin receptor are increase in the process of prostate carcinogenesis. This increase may adversely affect the clinical course of prostate cancer patients by stimulating angiogenesis, which is important for invasion and metastasis in prostate cancer. © 2022, Malaysian Society of Pathologists. All rights reserved.en_US
dc.description.sponsorshipAcknowledgments: This study was not supported by any financial institution.en_US
dc.identifier.endpage467en_US
dc.identifier.issn0126-8635
dc.identifier.issue3en_US
dc.identifier.pmid36591713en_US
dc.identifier.scopus2-s2.0-85145048465en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage461en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12574
dc.identifier.volume44en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSoylu, Hakan
dc.language.isoenen_US
dc.publisherMalaysian Society of Pathologistsen_US
dc.relation.ispartofMalaysian Journal of Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectApelinen_US
dc.subjectapelin receptoren_US
dc.subjectcanceren_US
dc.subjectHGPINen_US
dc.subjectprostateen_US
dc.subjectapelinen_US
dc.subjectapelin receptoren_US
dc.subjectd4293en_US
dc.subjectdiaminobenzidineen_US
dc.subjecthematoxylinen_US
dc.subjecthydrogen peroxideen_US
dc.subjecthypoxia inducible factor 1alphaen_US
dc.subjectmhs32en_US
dc.subjectapelin receptoren_US
dc.subjectangiogenesisen_US
dc.subjectArticleen_US
dc.subjectbreast carcinomaen_US
dc.subjectcarcinogenesisen_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectdysplasiaen_US
dc.subjectgene expressionen_US
dc.subjecthistopathologyen_US
dc.subjecthumanen_US
dc.subjecthuman tissueen_US
dc.subjecthypoxiaen_US
dc.subjectimmunohistochemistryen_US
dc.subjectprostate adenocarcinomaen_US
dc.subjectprostate canceren_US
dc.subjectprostate tissueen_US
dc.subjectprostatectomyen_US
dc.subjectprostatic intraepithelial neoplasiaen_US
dc.subjectadenocarcinomaen_US
dc.subjectmaleen_US
dc.subjectmetabolismen_US
dc.subjectpathologyen_US
dc.subjectprostateen_US
dc.subjectprostate tumoren_US
dc.subjectsquamous cell carcinomaen_US
dc.subjectAdenocarcinomaen_US
dc.subjectApelinen_US
dc.subjectApelin Receptorsen_US
dc.subjectCarcinoma, Squamous Cellen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectProstateen_US
dc.subjectProstatic Intraepithelial Neoplasiaen_US
dc.subjectProstatic Neoplasmsen_US
dc.titleEvaluation of angiogenic apelin/apelin receptor axis in normal prostate, high grade prostatic intraepithelial neoplasia and prostatic adenocarcinomaen_US
dc.typeArticleen_US

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