Evaluation of angiogenic apelin/apelin receptor axis in normal prostate, high grade prostatic intraepithelial neoplasia and prostatic adenocarcinoma
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Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Malaysian Society of Pathologists
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Introduction and Objectives: Prostate cancer is one of the most commonly diagnosed cancers in American men. Apelin is an endogenous peptide identified as the ligand of the G protein-associated apelin receptor. Apelin and apelin receptor have many tissues distribution and they participate in pathological processes, such as cancer. Apelin stimulates cancer angiogenesis. However, there are insufficient data in the literature regarding the role of apelin/apelin receptor in normal tissue, high-grade prostatic intraepithelial neoplasia, and prostatic adenocarcinoma tissues. Therefore, this study aimed to investigate the apelin and apelin receptor expression levels in tissues of normal prostate tissue, high-grade prostatic intraepithelial neoplasia, and prostatic adenocarcinoma. Materials and Methods: In this study, 38 samples of patients undergoing radical prostatectomy were used. Among 38 samples; 20 patients were with prostatic adenocarcinoma, 18 patients were with high-grade prostatic intraepithelial neoplasia and adjacent normal prostatic tissue areas. The immunolocalisation of apelin and apelin receptor in these tissues were determined immunohistochemically. Results: Apelin and apelin receptor expressions were higher in prostatic adenocarcinoma than normal prostate tissue and high-grade prostatic intraepithelial neoplasia. Apelin receptor expression was also increased in high-grade prostatic intraepithelial neoplasia compared to normal tissue. Conclusion: Apelin and apelin receptor are increase in the process of prostate carcinogenesis. This increase may adversely affect the clinical course of prostate cancer patients by stimulating angiogenesis, which is important for invasion and metastasis in prostate cancer. © 2022, Malaysian Society of Pathologists. All rights reserved.
Açıklama
Anahtar Kelimeler
Apelin, apelin receptor, cancer, HGPIN, prostate, apelin, apelin receptor, d4293, diaminobenzidine, hematoxylin, hydrogen peroxide, hypoxia inducible factor 1alpha, mhs32, apelin receptor, angiogenesis, Article, breast carcinoma, carcinogenesis, clinical article, controlled study, dysplasia, gene expression, histopathology, human, human tissue, hypoxia, immunohistochemistry, prostate adenocarcinoma, prostate cancer, prostate tissue, prostatectomy, prostatic intraepithelial neoplasia, adenocarcinoma, male, metabolism, pathology, prostate, prostate tumor, squamous cell carcinoma, Adenocarcinoma, Apelin, Apelin Receptors, Carcinoma, Squamous Cell, Humans, Male, Prostate, Prostatic Intraepithelial Neoplasia, Prostatic Neoplasms
Kaynak
Malaysian Journal of Pathology
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
44
Sayı
3
