Impact of lipid emulsions in parenteral nutrition on platelets: a literature review

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dc.authoridKisioglu-Halis, Betul/0000-0002-7158-9524en_US
dc.authorscopusid57202748606en_US
dc.authorscopusid59022744900en_US
dc.contributor.authorKisioglu, Betul
dc.contributor.authorTamer, Funda
dc.date.accessioned2024-08-23T16:04:31Z
dc.date.available2024-08-23T16:04:31Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractLipid emulsions are essential components of parenteral nutrition solutions that provide energy and essential fatty acids. The complexity of the formulations of lipid emulsions may lead to adverse outcomes such as platelet reactivity and changes in platelet aggregation and related coagulation. Platelets are responsible for haemostasis; they activate and demonstrate morphological changes upon extracellular factors to maintain blood fluidity and vascular integrity. Although parenteral nutrition lipid emulsions are generally found safe with regard to modulation of platelet activity, studies are still accumulating. Thus, this review aims to investigate platelet-related changes by parenteral nutrition lipid emulsions in human studies. Studies have pointed out patients at risk of bleeding and increased platelet aggregation responses due to the administration of lipid emulsions. Lipid emulsions may further benefit patients at high risk of thrombosis due to anti-thrombotic effects and should be cautiously used in patients with thrombocytopenia. The reported platelet-related changes might be associated with the fatty acid change in the plasma membranes of platelets following changes in platelet synthesis and plasma levels of eicosanoids. In conclusion, studies investigating platelets and parenteral nutrition should be supported to minimize the adverse effects and to benefit from the potential protective effects of parenteral nutrition lipid emulsions.en_US
dc.identifier.doi10.1017/jns.2024.11
dc.identifier.issn2048-6790
dc.identifier.pmid38572365en_US
dc.identifier.scopus2-s2.0-85188736787en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1017/jns.2024.11
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14243
dc.identifier.volume13en_US
dc.identifier.wosWOS:001196284700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofJournal of Nutritional Scienceen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLipid emulsionsen_US
dc.subjectlipidsen_US
dc.subjectparenteral nutritionen_US
dc.subjectplatelet function testsen_US
dc.subjectplateletsen_US
dc.subjectFatty-Acid-Compositionen_US
dc.subjectBolus Intravenous-Injectionen_US
dc.subjectLong-Chain Triglyceridesen_US
dc.subject10-Percent Fish-Oilen_US
dc.subjectIntralipid Infusionen_US
dc.subjectDouble-Blinden_US
dc.subjectOlive Oilen_US
dc.subjectPlasmaen_US
dc.subjectAggregationen_US
dc.subjectChildrenen_US
dc.titleImpact of lipid emulsions in parenteral nutrition on platelets: a literature reviewen_US
dc.typeReviewen_US

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