Therapeutic effect of curcumin and C60 fullerene against hyperglycemia-mediated tissue damage in diabetic rat lungs

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dc.contributor.authorDemir, Ersin
dc.date.accessioned2021-12-01T18:46:56Z
dc.date.available2021-12-01T18:46:56Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractIncreasing evidence suggests that diabetes also targets lung tissues resulting in structural and physiological abnormalities. The present study evaluated the impact of pristine C60 fullerene (C60) against diabetes-induced lung damage for the first time. The objective was to evaluate the impacts of Curcumin (Cur), C60 and C60 fullerene+Curcumin (C60 + Cur) combination on oxidative stress (MDA, GSH, CAT, GST, Retinol, alpha-tocopherol), apoptosis (Caspase-3, Bcl-2), cholesterol and fatty acid profile (16:0,18:0,18:1,18:2, 22:4, 22:6) against changes in the lung tissue of diabetic rats. Streptozotocin (STZ) was used for inducing diabetes with Cur, C60 and C60 + Cur combination administered for eight weeks to treat diabetic and control rats. Increased oxidative stress, apoptosis and significant changes in cell structure were observed in the lung tissues of diabetic rats. The combination of Cur, C60 and C60 + Cur reduced oxidative stress in the lung tissue of diabetic rats while increasing the antioxidant defense capacity of the tissue, exhibiting tissue protective properties against apoptosis. The diabetic rats displayed favorable properties against lipotoxicity-induced tissue damage due to the increase in the fatty acid and cholesterol levels in lung tissue. It was observed that Cur, C60 and C60 + Cur combination displays protective effects against hyperglycemia induced oxidative damage to lung tissue. Oxidative stress, prevention of lipid and cholesterol accumulation, and weakening of lung apoptosis may be associated with these effects.en_US
dc.description.sponsorshipScientific Research Projects Unit of DuzceUniversity [BAP-2017.11.05.657]en_US
dc.description.sponsorshipPart of this work was supported by the Scientific Research Projects Unit of DuzceUniversity (Grant number: BAP-2017.11.05.657).en_US
dc.identifier.doi10.1007/s10863-020-09861-5
dc.identifier.endpage38en_US
dc.identifier.issn0145-479X
dc.identifier.issn1573-6881
dc.identifier.issue1en_US
dc.identifier.pmid33411205en_US
dc.identifier.scopus2-s2.0-85099079897en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://doi.org/10.1007/s10863-020-09861-5
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10061
dc.identifier.volume53en_US
dc.identifier.wosWOS:000605884900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorDemir, Ersin
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofJournal Of Bioenergetics And Biomembranesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectOxidative stressen_US
dc.subjectApoptosisen_US
dc.subjectCurcuminen_US
dc.subjectLipotoxicityen_US
dc.subjectPristine C60 fullerenen_US
dc.subjectMesenchymal Stem-Cellsen_US
dc.subjectOxidative Stressen_US
dc.subjectFatty-Aciden_US
dc.subjectAntioxidant Statusen_US
dc.subjectAlpha-Tocopherolen_US
dc.subjectApoptosisen_US
dc.subjectLiveren_US
dc.subjectInjuryen_US
dc.subjectC-60en_US
dc.subjectImprovesen_US
dc.titleTherapeutic effect of curcumin and C60 fullerene against hyperglycemia-mediated tissue damage in diabetic rat lungsen_US
dc.typeArticleen_US

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