Evaluation of Argyrophilic Nucleolar Organizing Region-Associated Protein Synthesis in Femoral Muscle Cells of Rats Exposed to 3000 ppm Carbon Monoxide Gas

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dc.contributor.authorEröz, Recep
dc.contributor.authorSarıtaş, Ayhan
dc.contributor.authorÇolakoğlu, Serdar
dc.contributor.authorOktay, Murat
dc.contributor.authorKandiş, Hayati
dc.date.accessioned2020-05-01T12:11:56Z
dc.date.available2020-05-01T12:11:56Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000372103700003en_US
dc.description.abstractObjective: Carbon monoxide (CO) is a colorless, tasteless, odorless, and nonirritant gas and it causes tissues hypoxia due to decreasing oxygen carrying capacity. Nucleolar-organizing regions (NORs) are genetic loci on chromosomes and they can be stained with silver when they are active. In this study, we aimed to investigate any possible effects 3000 ppm CO exposure on the NOR protein synthesis in femoral muscle cells of rats. Method: The animals were divided into 2 groups as control (C) and 3000 ppm CO exposed group. One week after exposure to CO, the animals were anesthetized and femoral muscle tissues were obtained. Then mean argyrophilic NOR (AgNOR) number and total AgNOR area/nuclear area (TAA/NA) were detected in femoral muscle cells for each rat. Results: There were significant differences between control group and 3000 ppm CO exposed group for mean AgNOR number (Z=-6.407 and p=0.000) and TAA/NA ratio (Z=-7.718 and p=0.000). Conclusion: It was detected that there were a possible effects of CO exposure on the AgNOR proteins amounts in femoral muscle cells of rats.en_US
dc.identifier.endpage13en_US
dc.identifier.issn1309-3878
dc.identifier.issue1en_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6294
dc.identifier.volume8en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDuzce Univen_US
dc.relation.ispartofKonuralp Tip Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgNORsen_US
dc.subjectNORen_US
dc.subjectCarbon monoxideen_US
dc.subjectmuscle cellsen_US
dc.titleEvaluation of Argyrophilic Nucleolar Organizing Region-Associated Protein Synthesis in Femoral Muscle Cells of Rats Exposed to 3000 ppm Carbon Monoxide Gasen_US
dc.typeArticleen_US

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