Radiologic and histopathologic effects of favipiravir and hydroxychloroquine on fracture healing in rats

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dc.authoridkaraduman, zekeriya okan/0000-0002-6719-3666en_US
dc.authoridARİCAN, MEHMET/0000-0002-0649-2339en_US
dc.authoridUludağ, Veysel/0000-0002-9911-5961en_US
dc.authorscopusid59124610900en_US
dc.authorscopusid55353048000en_US
dc.authorscopusid57209297847en_US
dc.authorscopusid23768513300en_US
dc.authorscopusid57215363582en_US
dc.authorscopusid58172080400en_US
dc.authorscopusid57212620333en_US
dc.authorwosidkaraduman, zekeriya okan/AAD-6650-2020en_US
dc.authorwosidARİCAN, MEHMET/AAD-2463-2020en_US
dc.authorwosidUludağ, Veysel/ABZ-8655-2022en_US
dc.contributor.authorTekce, Giray
dc.contributor.authorArican, Mehmet
dc.contributor.authorKaraduman, Zekeriya Okan
dc.contributor.authorTurhan, Yalcin
dc.contributor.authorSaglam, Sonmez
dc.contributor.authorYucel, Muecahid Osman
dc.contributor.authorCoskun, Sinem Kantarcioglu
dc.date.accessioned2024-08-23T16:07:16Z
dc.date.available2024-08-23T16:07:16Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractFracture healing is a process in which many factors interact. In addition to many treatments, physical and biological therapy methods that affect different steps of this process, there are many biological and chemical agents that cause fracture union delay. Although the number of studies on fracture healing is increasing day by day, the mechanism of fracture healing, which is not fully understood, still attracts the attention of all researchers. In this study, we aimed to investigate the effects of favipiravir and hydroxychloroquine used in the treatment of COVID-19. In this study, 48 male Wistar rats weighing 300 +/- 50 g were used. Each group was divided into eight subgroups of six rats each to be sacrificed at the 2nd and 4th weeks and evaluated radiologically and histologically. Favipiravir (group 1), hydroxychloroquine (group 2), favipiravir + hydroxychloroquine (group 3), and random control (group 4) were used. A statistically significant difference was observed between the 15th day histological scoring averages of the groups (p < 0.05). Although there was no statistically significant difference between the 15th day radiological score distributions of the groups (p > 0.05), we obtained different results in terms of complete bone union distributions and radiological images of the fracture line. Although favipiravir has a negative effect on fracture union in the early period, favipiravir may have a positive effect on fracture union in the late period. We did not find any effect of hydroxychloroquine on fracture union.en_US
dc.description.sponsorshipDuzce Universityen_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.1007/s00210-024-03147-y
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.pmid38743116en_US
dc.identifier.scopus2-s2.0-85192935691en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s00210-024-03147-y
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14555
dc.identifier.wosWOS:001222579200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNaunyn-Schmiedebergs Archives of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFracture healingen_US
dc.subjectHydroxychloroquineen_US
dc.subjectRaten_US
dc.subjectFavipiraviren_US
dc.subjectT-705en_US
dc.subjectCareen_US
dc.titleRadiologic and histopathologic effects of favipiravir and hydroxychloroquine on fracture healing in ratsen_US
dc.typeArticleen_US

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