Evaluation of angiogenic apelin/apelin receptor axis in normal prostate, high grade prostatic intraepithelial neoplasia and prostatic adenocarcinoma

Basit Öğe Kaydı
dc.authoridSoylu, Hakan/0000-0002-1177-2351en_US
dc.authoridavcı, sema/0000-0002-2860-5592;en_US
dc.authorwosidSoylu, Hakan/I-8911-2017en_US
dc.authorwosidavcı, sema/I-8850-2017en_US
dc.authorwosidCAYLAN, Ahmet Ender/HHT-1176-2022en_US
dc.contributor.authorSoylu, Hakan
dc.contributor.authorUnal, Betul
dc.contributor.authorAksu, Kubra
dc.contributor.authorAvci, Sema
dc.contributor.authorCaylan, Ahmet Ender
dc.contributor.authorUstunel, Ismail
dc.date.accessioned2024-08-23T16:07:19Z
dc.date.available2024-08-23T16:07:19Z
dc.date.issued2022en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractIntroduction and Objectives: Prostate cancer is one of the most commonly diagnosed cancers in American men. Apelin is an endogenous peptide identified as the ligand of the G protein-associated apelin receptor. Apelin and apelin receptor have many tissues distribution and they participate in pathological processes, such as cancer. Apelin stimulates cancer angiogenesis. However, there are insufficient data in the literature regarding the role of apelin/apelin receptor in normal tissue, highgrade prostatic intraepithelial neoplasia, and prostatic adenocarcinoma tissues. Therefore, this study aimed to investigate the apelin and apelin receptor expression levels in tissues of normal prostate tissue, high-grade prostatic intraepithelial neoplasia, and prostatic adenocarcinoma. Materials and Methods: In this study, 38 samples of patients undergoing radical prostatectomy were used. Among 38 samples; 20 patients were with prostatic adenocarcinoma, 18 patients were with high-grade prostatic intraepithelial neoplasia and adjacent normal prostatic tissue areas. The immunolocalisation of apelin and apelin receptor in these tissues were determined immunohistochemically. Results: Apelin and apelin receptor expressions were higher in prostatic adenocarcinoma than normal prostate tissue and high-grade prostatic intraepithelial neoplasia. Apelin receptor expression was also increased in high-grade prostatic intraepithelial neoplasia compared to normal tissue. Conclusion: Apelin and apelin receptor are increase in the process of prostate carcinogenesis. This increase may adversely affect the clinical course of prostate cancer patients by stimulating angiogenesis, which is important for invasion and metastasis in prostate cancer.en_US
dc.identifier.endpage467en_US
dc.identifier.issn0126-8635
dc.identifier.issue3en_US
dc.identifier.pmid36591713en_US
dc.identifier.startpage461en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14590
dc.identifier.volume44en_US
dc.identifier.wosWOS:000956548700008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMalaysian Journal Pathologyen_US
dc.relation.ispartofMalaysian Journal of Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApelinen_US
dc.subjectapelin receptoren_US
dc.subjectHGPINen_US
dc.subjectprostateen_US
dc.subjectcanceren_US
dc.subjectApelin Expressionen_US
dc.subjectSerum Apelinen_US
dc.subjectCanceren_US
dc.subjectHypoxiaen_US
dc.subjectPrognosisen_US
dc.subjectBreasten_US
dc.titleEvaluation of angiogenic apelin/apelin receptor axis in normal prostate, high grade prostatic intraepithelial neoplasia and prostatic adenocarcinomaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu