Usefulness of admission matrix metalloproteinase 9 as a predictor of early mortality after cardiopulmonary resuscitation in cardiac arrest patients

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dc.contributor.authorTürkdoğan, Kenan Ahmet
dc.contributor.authorZorlu, Ali
dc.contributor.authorGüven, Fatma Mutlu Kukul
dc.contributor.authorEkinözü, İsmail
dc.contributor.authorEryiğit, Umut
dc.contributor.authorYılmaz, Mehmet Birhan
dc.date.accessioned2020-04-30T23:46:52Z
dc.date.available2020-04-30T23:46:52Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionYILMAZ, MEHMET BIRHAN B/0000-0002-8169-8628; YILMAZ, Mehmet Birhan/0000-0002-8169-8628; YILMAZ, MEHMET BIRHAN/0000-0002-8169-8628; kukul guven, fatma mutlu/0000-0003-3755-6021en_US
dc.descriptionWOS: 000311997600021en_US
dc.descriptionPubMed: 22633700en_US
dc.description.abstractBackground: Matrix metalloproteinases (MMPs) have a central role in disease progression after ischemia-reperfusion injury. However, its prognostic significance in cardiac arrest (CA) patients having cardiopulmonary resuscitation (CPR) is unknown. The aim of this study was to investigate the relation between admission MMP-9 level and early mortality in CA patients. Methods: A total of 96 in-hospital or out-of-hospital CA patients and 40 age-and sex-matched healthy volunteers as the control group were evaluated prospectively. The patients were classified according to the CPR response into a successful group (n = 46) and a failed group (n = 50). Results: The MMP-9 levels were detected to be 56.9 +/- 4.3, 69.5 +/- 7.4, and 92.7 +/- 10.1 ng/mL in the control group, the successful CPR group (acute responders), and the failed CPR group, respectively (P < .001 for the 2 comparisons). The MMP-9 level on admission, presence of asystole, mean CA duration, out-of-hospital CPR, sodium and potassium levels, and arterial pH were found to have prognostic significance in univariate analysis. In addition, MMP-9 levels were correlated with age, troponin level, and oxygen saturation. In multivariate logistic regression analysis with forward stepwise method, only MMP-9 level on admission (odds ratio, 1.504; P < .001) and mean CA duration before CPR (odds ratio, 1.257; P = .019) remained associated with post-CPR early mortality after adjustment of other potential confounders. In addition, optimal cutoff value of MMP-9 to predict failed CPR was found as greater than 82 ng/mL, with 88% sensitivity and 97.8% specificity. Conclusions: High MMP-9 levels were associated with worse clinical and laboratory parameters, and it seems that MMP-9 helps risk stratification in CA patients. (C) 2012 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.ajem.2012.02.017en_US
dc.identifier.endpage1809en_US
dc.identifier.issn0735-6757
dc.identifier.issue9en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1804en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajem.2012.02.017
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5328
dc.identifier.volume30en_US
dc.identifier.wosWOS:000311997600021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofAmerican Journal Of Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleUsefulness of admission matrix metalloproteinase 9 as a predictor of early mortality after cardiopulmonary resuscitation in cardiac arrest patientsen_US
dc.typeArticleen_US

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