Investigation of Microvascular Involvement Through Nailfold Capillaroscopic Examination in Children with Familial Mediterranean Fever

Basit Öğe Kaydı
dc.authoridUyar, Belkiz/0000-0003-3687-6760;
dc.contributor.authorKurt, Fatih
dc.contributor.authorUyar, Belkiz
dc.contributor.authorErguven, Muferet
dc.contributor.authorCangur, Sengul
dc.date.accessioned2025-10-11T20:47:43Z
dc.date.available2025-10-11T20:47:43Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground and Objectives: Familial Mediterranean fever (FMF) is a lifelong autoinflammatory disease characterized by episodes of fever and aseptic polyserositis. Commonly associated with vasculitis, FMF's impact on microcirculation was investigated by examining nailfold capillaries using capillaroscopy. Materials and Methods: This study included 32 female and 28 male FMF patients diagnosed according to the Tel Hashomer and Yal & ccedil;& imath;nkaya criteria and a control group of 20 female and 10 male age-matched cases. Demographic characteristics, medical history (abdominal pain, fever, chest pain, and joint pain), and physical examination findings of the cases were assessed. FMF gene mutations, acute-phase reactants, urine analysis, and spot urine protein/creatinine ratios were evaluated. Nailfold capillaries were examined via capillaroscopy by the same dermatology specialist. Results: There was no significant age or gender difference between groups. The most common symptoms in the case group were abdominal pain (81.7%) and joint pain (65%). Pathological findings in capillaroscopy, such as microhemorrhages and avascular areas, were significantly more frequent in the FMF case group (p < 0.001; p < 0.001). Physiological findings, including hairpin-shaped capillaries and shortened loops, were significantly more common in the control group (p = 0.001; p = 0.034). No significant relationships were found between kidney involvement, subclinical inflammation, presence of microhemorrhages and avascular areas in capillaroscopy, and disease duration. Additionally, no significant differences were observed in capillaroscopic findings between those with exon-10 mutations in the MEFV gene and those with non-exon-10 mutations. Conclusions: In conclusion, our study demonstrated secondary microvascular findings due to inflammation in FMF patients using capillaroscopy, a cost-effective and safe tool.en_US
dc.identifier.doi10.3390/medicina61020264
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue2en_US
dc.identifier.pmid40005381en_US
dc.identifier.scopus2-s2.0-85219039649en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/medicina61020264
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21540
dc.identifier.volume61en_US
dc.identifier.wosWOS:001430816300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMedicina-Lithuaniaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectFMFen_US
dc.subjectcapillaroscopyen_US
dc.subjectmicrohemorrhageen_US
dc.subjectavascular areasen_US
dc.titleInvestigation of Microvascular Involvement Through Nailfold Capillaroscopic Examination in Children with Familial Mediterranean Feveren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu