Early enteral and glutamine enriched enteral feeding ameliorates healing of colonic anastomosis: Experimental study

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dc.contributor.authorGökpınar, İbrahim
dc.contributor.authorGürleyik, Emin
dc.contributor.authorPehlivan, Mevlüt
dc.contributor.authorÖzcan, Ömer
dc.contributor.authorÖzaydın, İsmet
dc.contributor.authorAslaner, Arif
dc.contributor.authorGültepe, Mustafa
dc.date.accessioned2020-04-30T13:32:21Z
dc.date.available2020-04-30T13:32:21Z
dc.date.issued2006
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionPubMed ID: 16456746en_US
dc.description.abstractBACKGROUND: To investigate the effects of postoperative early enteral and glutamine enriched enteral feeding on the healing of experimental colonic anastomosis. METHODS: Forty Wistar-albino rats were equally divided into 4 groups. Colonic transsection and anastomosis situated at the distal left colon was performed on all animals. Animals in groups 1 and 2 received late total enteral nutrition (TEN) and in groups 3 and 4 early TEN. Glutamine was added to TEN protocol in groups 2 and 4. The colonic segment including the anastomosis was excised at the end of the 7th day postoperatively. Bursting pressure of the anastomosis and tissue hydroxyproline levels were determined. RESULTS: Bursting pressure levels were 111.6 and 95.8 centimeters of water (cmH2O) in early and late nutrition groups, respectively (p=0.022). Comparison of late TEN groups showed a significant difference in favor of group with glutamine (95.8 vs 138.5 cmH2O; p<0.0001). Highest bursting pressures (139 and 138.5 cmH2O) were measured in both early and late TEN groups with glutamine. Tissue hydroxyproline level in early TEN group (2440.3 ?g) was significantly higher than late TEN group (1509.6 ?g; p=0.024). Comparison of late TEN groups showed a considerable but not statistically significant difference (p=0.276) in favor of group with glutamine (1509.6 vs 1981.6 ?g). CONCLUSION: Postoperative early TEN significantly ameliorates the resistance of the anastomosis and collagen synthesis. Glutamine enrichment in nutritional protocol decreases and reverses the disadvantages of late TEN regarding the resistance of anastomosis. A similarly positive, albeit weaker, effect of glutamine supplementation is also seen on collagen synthesis.en_US
dc.identifier.endpage21en_US
dc.identifier.issn1300-6738
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage17en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/246
dc.identifier.volume12en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherTurkish Association of Trauma and Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma ve Acil Cerrahi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnastomosis, surgical; Colon/surgery; Enteral nutrition; Glutamine; Hydroxyproline; Parenteral nutrition; Postoperative care/methods; Rats, Wistar; Wound healingen_US
dc.titleEarly enteral and glutamine enriched enteral feeding ameliorates healing of colonic anastomosis: Experimental studyen_US
dc.title.alternativeErken enteral ve glutaminli enteral beslenmenin kolon anastomoz iyileşmesine etkisi: Deneysel çalişmaen_US
dc.typeArticleen_US

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