Clinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Units

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dc.authorwosidSahin, Taha Koray/ABH-1748-2020
dc.contributor.authorGundogan, Kursat
dc.contributor.authorAkbudak, Ismail Hakki
dc.contributor.authorHanci, Pervin
dc.contributor.authorHalacli, Burcin
dc.contributor.authorTemel, Sahin
dc.contributor.authorGullu, Zuhal
dc.contributor.authorYuksel, Recep Civan
dc.date.accessioned2021-12-01T18:51:15Z
dc.date.available2021-12-01T18:51:15Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractBackground: There are limited data on the long-term outcomes of COVID-19 from different parts of the world. Aims: To determine risk factors of 90-day mortality in critically ill patients in Turkish intensive care units (ICUs), with respiratory failure. Study design: Retrospective, observational cohort. Methods: Patients with laboratory-confirmed COVID-19 and who had been followed up in the ICUs with respiratory failure for more than 24 hours were included in the study. Their demographics, clinical characteristics, laboratory variables, treatment protocols, and survival data were recorded. Results: A total of 421 patients were included. The median age was 67 (IQR: 57-76) years, and 251 patients (59.6%) were men. The 90-day mortality rate was 55.1%. The factors independently associated with 90-day mortality were invasive mechanical ventilation (IMV) (HR 4.09 [95% CI: [2.20-7.63], P<.001), lactate level >2 mmol/L (2.78 [1.93-4.01], P<.001), age >= 60 years (2.45 [1.48-4.06)], P<.001), cardiac arrhythmia during ICU stay (2.01 [1.27-3.20], P=.003), vasopressor treatment (1.94 [1.32-2.84], P=.001), positive fluid balance of >= 600 mL/day (1.68 [1.21-2.34], P=.002), PaO2/FiO(2) ratio of <= 150 mmHg (1.66 [1.18-2.32], P=.003), and ECOG score >= 1 (1.42 [1.00-2.02], P=.050). Conclusion: Long-term mortality was high in critically ill patients with COVID-19 hospitalized in intensive care units in Turkey. Invasive mechanical ventilation, lactate level, age, cardiac arrhythmia, vasopressor therapy, positive fluid balance, severe hypoxemia and ECOG score were the independent risk factors for 90-day mortality.en_US
dc.identifier.doi10.5152/balkanmedj.2021.21188
dc.identifier.endpage+en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue5en_US
dc.identifier.pmid34558415en_US
dc.identifier.scopus2-s2.0-85115428262en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage296en_US
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2021.21188
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10986
dc.identifier.volume38en_US
dc.identifier.wosWOS:000700853600007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFluid Balanceen_US
dc.subjectCovid-19en_US
dc.titleClinical Outcomes and Independent Risk Factors for 90-Day Mortality in Critically Ill Patients with Respiratory Failure Infected with SARS-CoV-2: A Multicenter Study in Turkish Intensive Care Unitsen_US
dc.typeArticleen_US

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