Beyond pelvic pathology: retinal microvascular rarefaction as a systemic marker in endometriosis

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dc.authoridMEYDAN, BAYRAM/0000-0002-7752-6516
dc.authoridKeyif, Betul/0000-0002-7472-551X
dc.contributor.authorKeyif, Betul
dc.contributor.authorSezer, Taha
dc.contributor.authorColak, Kubra
dc.contributor.authorGundogdu, Zulfiye Balkan
dc.contributor.authorMeydan, Bayram
dc.date.accessioned2025-10-11T20:48:09Z
dc.date.available2025-10-11T20:48:09Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective This study aimed to quantitatively assess retinal microvascular alterations in women with pelvic endometriosis using optical coherence tomography angiography (OCTA), and to explore whether these subclinical findings may reflect early signs of systemic microvascular alterations in this population. Methods In this retrospective cross-sectional study, 100 eyes were analyzed-50 from women with laparoscopically or ultrasonographically confirmed pelvic endometriosis and 50 from age-matched healthy female controls. All participants underwent comprehensive ophthalmic examinations and macular OCTA imaging using the Heidelberg Spectralis system. Quantitative parameters, including vessel area density (VAD), foveal avascular zone (FAZ) metrics (area, perimeter, circularity), and FD-300 values, were extracted from the superficial and deep capillary plexuses using the OCTAVA software. Segmental parafoveal VAD values (nasal, temporal, superior, and inferior) were also assessed. Axial length measurements and endometriosis staging were not available in this retrospective dataset. Hormonal therapy use was not systematically documented. Results Compared to healthy controls, women with endometriosis demonstrated significantly lower total and parafoveal VAD and FD-300 values in both retinal plexuses (p < 0.05 for all). FAZ perimeter showed a modest but statistically significant difference, whereas FAZ area and circularity index remained comparable between groups. No participant in either group exhibited clinically visible retinal pathology. These alterations occurred despite preserved visual acuity and in the absence of systemic comorbidities known to affect microcirculation. Conclusion Although causality cannot be inferred from this cross-sectional design, our findings indicate that pelvic endometriosis is associated with region-specific subclinical reductions in retinal capillary perfusion, particularly within the foveal and parafoveal regions. OCTA-derived metrics, especially FD-300 and parafoveal VAD, may offer insight into microvascular integrity in this patient group. These results support further investigation into the systemic vascular aspects of endometriosis and highlight the potential utility of retinal imaging in exploring such associations.en_US
dc.identifier.doi10.1186/s12905-025-03899-6
dc.identifier.issn1472-6874
dc.identifier.issue1en_US
dc.identifier.pmid40640800en_US
dc.identifier.scopus2-s2.0-105010511900en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1186/s12905-025-03899-6
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21750
dc.identifier.volume25en_US
dc.identifier.wosWOS:001526859300002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofBmc Womens Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectEndometriosisen_US
dc.subjectFD-300en_US
dc.subjectOCTAen_US
dc.subjectRetinaen_US
dc.subjectVascular densityen_US
dc.titleBeyond pelvic pathology: retinal microvascular rarefaction as a systemic marker in endometriosisen_US
dc.typeArticleen_US

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