A comparative study of pre-operative imaging methods in patients with primary hyperparathyroidism: Ultrasonography, Tc-99m sestamibi, single photon emission computed tomography, and magnetic resonance imaging

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dc.contributor.authorAkbaba, Gülhan
dc.contributor.authorBerker, Dilek
dc.contributor.authorIşık, Serhat
dc.contributor.authorAydın, Yusuf
dc.contributor.authorCılız, Deniz Sözmen
dc.contributor.authorPeksoy, İrfan
dc.contributor.authorGüler, Serdar
dc.date.accessioned2020-04-30T22:38:37Z
dc.date.available2020-04-30T22:38:37Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000308045400003en_US
dc.descriptionPubMed: 21623148en_US
dc.description.abstractAim: This study compares the accuracy rates achieved in ultrasonography (US), 9(9m)Tc-sestamibi (MIBI), single photon emission computed tomography (SPEC), and magnetic resonance imaging (MRI) as imaging methods used in the pre-operative localization of the enlarged parathyroid glands. Subjects and methods: For the purposes of this study, US, MIBI, SPECT, and MRI were performed on 98 patients with primary hyperparathyroidism (pHPT). All patients underwent parathyroidectomy. Results: Pre-operative localization of an abnormal parathyroid gland was successfully performed in 82 of the cases scanned with US (83.7%), while the result was 66 in the cases scanned with MIBI (67.3%), 71 of the cases were successfully localized with SPECT (72.4%), while MRI revealed the diseased gland in only 60 of the total'cases (61.2%). In MIBI-positive and -negative patients there was a statistically significant difference among cases in terms of adenoma volume (1.30 +/- 1.51 vs 0.58 +/- 0.91, p < 0.05). Sensitivity, specificity and diagnostic accuracy values were 87.2%, 25.0%, and 83.0%; 70.2%, 50.0%, and 69.4%; 75.5%, 50.0%, and 74.5%; 63.8%, 50.0%, and 63.3% for US, MIBI, SPECT, and MRI, respectively. The respective values for sensitivity, specificity, and diagnostic accuracy were 94.9%, 25.0%, and 91.1% when US was combined with MIBI. Conclusions: Combining US and MIBI as imaging methods for pre-operative imaging of pHPT often produces more satisfactory results. While the accuracy of US is relatively low in the ectopic localizations, the size of the lesion can be an important factor in the accuracy achieved with MIBI. (J. Endocrinol. Invest. 35: 359-364, 2012) (c) 2012, Editrice Kurtisen_US
dc.identifier.doi10.3275/7764en_US
dc.identifier.endpage364en_US
dc.identifier.issn0391-4097
dc.identifier.issn1720-8386
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage359en_US
dc.identifier.urihttps://doi.org/10.3275/7764
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2323
dc.identifier.volume35en_US
dc.identifier.wosWOS:000308045400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectparathyroid scintigraphyen_US
dc.subjectprimary hyperparathyroidismen_US
dc.subjectSPECTen_US
dc.subjectultrasonographyen_US
dc.titleA comparative study of pre-operative imaging methods in patients with primary hyperparathyroidism: Ultrasonography, Tc-99m sestamibi, single photon emission computed tomography, and magnetic resonance imagingen_US
dc.typeArticleen_US

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