A novel prognostic indicator for in-hospital and 4-year outcomes in patients with pulmonary embolism: TIMI risk index

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dc.contributor.authorKeskin, Muhammed
dc.contributor.authorGüvenç, Tolga Sinan
dc.contributor.authorHayıroğlu, Mert İlker
dc.contributor.authorKaya, Adnan
dc.contributor.authorTatlısu, Mustafa Adem
dc.contributor.authorAvşar, Şahin
dc.contributor.authorKozan, Ömer
dc.date.accessioned2020-04-30T22:38:47Z
dc.date.available2020-04-30T22:38:47Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionGuvenc, Tolga Sinan/0000-0002-6738-266X; Keskin, Muhammed/0000-0002-4938-0097en_US
dc.descriptionWOS: 000415210400031en_US
dc.descriptionPubMed: 28575813en_US
dc.description.abstractBackground: Thrombolysis in Myocardial Infarction (TIMI) risk index (TRI) was recently evaluated in patients with acute myocardial infarction and found as an important prognostic index. In the current study, we evaluated the prognostic value of TRI in patients with moderate-high and high risk pulmonary embolism (PE) who were treated with thrombolytic agents. Methods: We retrospectively evaluated the in-hospital and long-term(4-year) prognostic impact of TRI in a total number of 456 patients with moderate-high and high risk PE. Patients were stratified by quartiles (Q) of admission TRI. Results: In-hospital analysis revealed significantly higher rates of in-hospital death for patients with TRI in Q4. After adjustment for confounding baseline variables, TRI in Q4 was associated with 2.8-fold hazard of in-hospital death. Upon multivariate analysis, admission TRI in Q4 vs. Q1-3 was associated with 3.1 fold hazard of 4-year mortality rate. Conclusion: TRI in Q4, as compared to Q1-3, was significantly predictive of short term and long-term outcomes in PE patients who treated with thrombolytic agents. Our data suggest TRI to be an independent, feasible, and cost effective tool for rapid risk stratification in moderate-high and high risk PE patients who treated with thrombolytic agents. (C) 2017 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jcrc.2017.05.018en_US
dc.identifier.endpage190en_US
dc.identifier.issn0883-9441
dc.identifier.issn1557-8615
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage183en_US
dc.identifier.urihttps://doi.org/10.1016/j.jcrc.2017.05.018
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2448
dc.identifier.volume41en_US
dc.identifier.wosWOS:000415210400031en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Critical Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTIMI risk indexen_US
dc.subjectPulmonary embolismen_US
dc.subjectMortalityen_US
dc.subjectRisk stratificationen_US
dc.titleA novel prognostic indicator for in-hospital and 4-year outcomes in patients with pulmonary embolism: TIMI risk indexen_US
dc.typeArticleen_US

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