Use of decorin to prevent epidural fibrosis in a post-laminectomy rat model

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dc.contributor.authorTürkoğlu, Erhan
dc.contributor.authorDinç, Cem
dc.contributor.authorTuncer, Cengiz
dc.contributor.authorOktay, Murat
dc.contributor.authorSerbes, Gökhan
dc.contributor.authorŞekerci, Zeki
dc.date.accessioned2020-04-30T13:34:02Z
dc.date.available2020-04-30T13:34:02Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionPubMed ID: 24374200en_US
dc.description.abstractThe formation of epidural fibrosis adjacent to the dura mater is a complex multi-step process that is associated with a marked reduction in tissue cellularity and the excessive deposition of extracellular matrix components. Extensive epidural fibrosis is a major cause of post-laminectomy syndrome. Decorin strongly inhibits fibrosis formation in various tissues via blockade of transforming growth factor-?1. The aim of this study was to investigate the effects of a topical application of decorin on the formation of epidural fibrosis in a rat laminectomy model. Twenty-four female Wistar albino rats (250-350 g) were equally and randomly divided into three groups (control, spongostan and decorin). Laminectomy was performed between the L3 and L5 levels in all rats. The dura mater was directly exposed to spongostan soaked with saline (2 cc/kg) or decorin (100 ?g/kg). Four weeks later, the laminectomized spine of the rats was completely removed between the L3 and L5 levels. The extent of the epidural fibrosis and arachnoidal involvement was histopathologically evaluated and graded. Our data revealed that epidural fibrosis was significantly reduced in the group treated with decorin compared to the spongostan and control groups (P<0.05). Our study demonstrates that the topical application of decorin can be effective in reducing the formation of epidural fibrosis in a simple laminectomy rat model. © 2013 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.ejphar.2013.12.017en_US
dc.identifier.endpage91en_US
dc.identifier.issn0014-2999
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage86en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejphar.2013.12.017
dc.identifier.urihttps://hdl.handle.net/20.500.12684/788
dc.identifier.volume724en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDecorin; Epidural fibrosis; Failed back surgery; Fibroblast; Laminectomy; Post-laminectomy syndromeen_US
dc.titleUse of decorin to prevent epidural fibrosis in a post-laminectomy rat modelen_US
dc.typeArticleen_US

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