Dynamic thiol disulphide homeostasis in patients with surfer's eye: a case-control study

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dc.authoridEREL, Ozcan/0000-0002-2996-3236
dc.authoridAkcam, Hanife Tuba/0000-0001-5111-2270
dc.contributor.authorAkcam, Hanife Tuba
dc.contributor.authorErel, Ozcan
dc.date.accessioned2021-12-01T18:49:04Z
dc.date.available2021-12-01T18:49:04Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractPurpose The role of oxidative stress in the pathogenesis of pterygium is still unclear. However, abnormal thiol disulfide homeostasis levels are involved in the pathogenesis of various systemic or ocular diseases. We aim to analyze dynamic thiol disulphide homeostasis in patients suffering from conjunctival pterygium using a contemporary technique. Methods Thirty-eight subjects suffering from pterygium and 35 age-gender matched healthy volunteers were recruited for the study. For each case, total thiol, disulfide and native thiol levels in blood were obtained. Additionally, the ratio of disulfide over total thiol, native thiol over total thiol and disulfide over native thiol were computed. Results The level of median native thiol was lower in pterygium group (318.2 mu mol/L vs. 333.4 mu mol/L) and median disulfide was slightly higher in pterygium group (24.3 mu mol/L vs. 22.8 mu mol/L) compared to control group. Both disulfide over total thiol and disulfide over native thiol ratios were higher in pterygium group, ratio of native thiol over total thiol was found to be higher in control group. Nevertheless, none of those differences were statistically significant at 95% confidence level. Notably, correlation test pointed to a negative correlation both between pterygium grade and native thiol and between total thiol and pterygium grade in pterygium group (P = 0.03 and 0.02, respectively). Conclusion A negative correlation hinting that slightly weakened dynamic thiol disulphide homeostasis in subjects with pterygium, a local ocular disease. Further studies with larger sample sizes may shed light on this potential relationship and justify systemic antioxidant therapies in these cases.en_US
dc.identifier.doi10.1007/s10792-021-02125-0
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.pmid34813011en_US
dc.identifier.scopus2-s2.0-85119883220en_US
dc.identifier.urihttps://doi.org/10.1007/s10792-021-02125-0
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10657
dc.identifier.wosWOS:000721628000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectConjunctivaen_US
dc.subjectCorneaen_US
dc.subjectPterygiumen_US
dc.subjectSurfer's eyeen_US
dc.subjectThiol disulphide homeostasisen_US
dc.subjectOxidative Stressen_US
dc.subjectThiol/Disulfide Homeostasisen_US
dc.subjectPterygiumen_US
dc.subjectRedoxen_US
dc.subjectAssayen_US
dc.subjectToolen_US
dc.titleDynamic thiol disulphide homeostasis in patients with surfer's eye: a case-control studyen_US
dc.typeArticleen_US

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