Can anti-adhesive efficacy of sodium hyaluronate and carboxymethylcellulose membrane be improved further by colchicine and collagenase?

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dc.contributor.authorSarohan, Aziz Rodan
dc.contributor.authorAlbayrak, Mustafa
dc.contributor.authorSomunkıran, Aslı
dc.contributor.authorÖzdemir, İsmail
dc.contributor.authorİskender, Abdülkadir
dc.contributor.authorSezen, Gülbin Yalçın
dc.contributor.authorDemiraran, Yavuz
dc.date.accessioned2020-04-30T13:32:10Z
dc.date.available2020-04-30T13:32:10Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: The aim of this study was to determine the impact of collagenase and colchicine in the prevention of postsurgical adhesion formation in a rat uterine horn model. Materials and Methods: Forty female Wistar albino rats were divided into four equal groups including controls, seprafilm, colchicine-seprafilm and collagenase-seprafilm groups. After laparotomy, a standard 0.5-cm injury was made to the antimesosalpingeal side of the right proximal uterine horn by unipolar cautery. After hemostasis, 0.5 cm seprafilm or colchicine 2 mg-0.5 cm seprafilm or collagenase 1?g - 0.5 cm seprafilm was applied to the site of injury. The abdominal incision was then sutured en bloc and the rats were observed for 20 days. Then, all rats were sacrified and second look laparotomy was performed. Macroscopic adhesion score of each rat was noted and histopathologic scoring was made according to Kanbour-Shakir criteria. Results: All of the five scores of the histologic parameters were lowest in the colchicineseprafilm group. The total histologic score of colchicine-seprafilm group was significantly lower than controls, seprafilm and collagenase-seprafilm groups (p<0.05). Conclusions: The results of this rat model suggested that local use of colchicines in the abdominal operations prevents formation of postsurgical adhesions based on both visual assessment and histological analyses. The promising result obtained from this experimental study needs further investigation. © 2011 Düzce Medical Journal.en_US
dc.identifier.endpage15en_US
dc.identifier.issn1307671X
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage10en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/136
dc.identifier.volume13en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColchicine; Collagenase; Postoperative Adhesions; Rat; Seprafilm; Uterine Hornen_US
dc.titleCan anti-adhesive efficacy of sodium hyaluronate and carboxymethylcellulose membrane be improved further by colchicine and collagenase?en_US
dc.title.alternativeSodyum hiyaluronat ve karboksimetilselluloz membranın anti- adezif etkinli?i kolşisin veya kollojenaz ile artırılabilir mi?en_US
dc.typeArticleen_US

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