Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study

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dc.authoridOzahi Ipek, Ilke/0000-0002-9120-7642
dc.authoridÖzer, Ömer Faruk/0000-0002-9034-4805
dc.authoridÖzde, Şükriye/0000-0002-0053-6222
dc.authorwosidÖzer, Ömer Faruk/Y-2516-2018
dc.contributor.authorErdoğan, Fırat
dc.contributor.authorSenkal, Evrim
dc.contributor.authorÖzer, Ömer Faruk
dc.contributor.authorIpek, Ilke Ozahi
dc.contributor.authorAltuntas, Sukriye Leyla
dc.contributor.authorÖzde, Şükriye
dc.date.accessioned2023-07-26T11:51:24Z
dc.date.available2023-07-26T11:51:24Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBACKGROUND: Reduced antioxidant defenses may reflect a poor protective response against oxidative stress and this may be implicated in progression of gestational diabetes mellitus (GDM). Oxidative stress induced by hyperglycemia plays a major role in micro and macrovascular complications, which imply endothelial dysfunction. OBJECTIVE: Our aim in this study was to investigate the association between GDM and oxidative stress markers measured in plasma, with regard to revealing changes to total antioxidant capacity (TAC) and total oxidant status (TOS) among mothers showing impairments in oral glucose tolerance tests (OGTTs). DESIGN AND SETTING: Prospective study at a university hospital in Turkey. METHODS: The study group consisted of 50 mothers with GDM, and 59 healthy mothers served as controls. Umbilical cord blood samples were taken from all mothers during delivery and breast milk samples on the fifth day after delivery. TAC, TOS, thiol and disulfide levels were measured. RESULTS: No statistically significant relationship between the blood and milk samples could be found. An analysis on correlations between TAC, TOS and certain parameters revealed that there were negative correlations between TOS and total thiol (r = -0.386; P < 0.001) and between TOS and disulfide (r = -0.388; P < 0.001) in milk in the control group. However, these findings were not observed in the study group. CONCLUSION: Our findings suggested that a compensatory mechanism of oxidative stress was expected to be present in gestational diabetes mellitus and that this might be ameliorated through good glycemic regulation and antioxidant supplementation.en_US
dc.identifier.doi10.1590/1516-3180.2021.0209.R1.25082021
dc.identifier.endpage397en_US
dc.identifier.issn1516-3180
dc.identifier.issue3en_US
dc.identifier.pmid35508001en_US
dc.identifier.scopus2-s2.0-85131699864en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage390en_US
dc.identifier.urihttps://doi.org/10.1590/1516-3180.2021.0209.R1.25082021
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12553
dc.identifier.volume140en_US
dc.identifier.wosWOS:000806210800011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÖzde, Şükriye
dc.language.isoenen_US
dc.publisherAssociacao Paulista Medicinaen_US
dc.relation.ispartofSao Paulo Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectDiabetes Mellitus; Gestational; Stress; Oxidative; Antioxidantsen_US
dc.subjectAntioxidant Capacity; Insulin; Supplementation; Dysfunction; Pregnancy; Children; Infants; Markers; Plasma; Tissueen_US
dc.titleOxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective studyen_US
dc.typeArticleen_US

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