Elevated Cadmium Levels in Dialysis Patients and Their Links to Inflammation, Oxidative Stress, and Malnutrition

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dc.contributor.authorOnec, Kursad
dc.contributor.authorErten, Yasemin
dc.contributor.authorPasaoglu, Ozge Tugce
dc.contributor.authorEbinc, Fatma Ayerden
dc.contributor.authorOkyay, Gulay Ulusal
dc.contributor.authorInal, Salih
dc.contributor.authorDeger, Serpil Muge
dc.date.accessioned2026-07-01T11:39:29Z
dc.date.available2026-07-01T11:39:29Z
dc.date.issued2025
dc.departmentDüzce Üniversitesi
dc.description.abstractAim: This study aimed to compare blood cadmium (Cd) levels between hemodialysis (HD) and peritoneal dialysis (PD) patients and healthy controls, and to evaluate the associations between Cd levels and inflammatory, oxidative, and nutritional markers. Material and Methods: Sixty-one dialysis patients (31 HD, 30 PD) and 15 healthy controls were included in this cross-sectional study. Whole-blood Cd was measured by atomic absorption spectrometry and corrected for hemoglobin (cCd). Serum interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), and advanced oxidation protein products (AOPP) were analyzed as indicators of inflammation and oxidative stress. Results: Both whole-blood Cd and cCd levels were significantly higher in both HD and PD patients compared with healthy controls (p=0.021 and p=0.001, respectively), while no statistically significant difference was observed between the two dialysis modalities. Correlation analyses demonstrated that Cd levels were positively correlated with inflammatory and oxidative stress markers, including IL-6 (rs=0.338, p=0.003), hs-CRP (rs=0.464, p=0.001), MDA (rs=0.464, p=0.001), and AOPP (rs=0.454, p<0.001). In contrast, cCd levels showed a significant negative correlation with serum albumin concentrations (rs=-0.454, p=0.001). Conclusion: Cd accumulation is markedly increased in dialysis patients regardless of treatment modality and is closely linked to systemic inflammation, oxidative damage, and reduced nutritional status. Environmental Cd exposure may represent an under-recognized contributor to adverse clinical outcomes in chronic kidney disease (CKD), and preventive strategies to minimize Cd burden may help improve prognosis in this population.
dc.identifier.doi10.18678/dtfd.1808654
dc.identifier.endpage351
dc.identifier.issn1307-671X
dc.identifier.issue3
dc.identifier.scopus2-s2.0-105028284616
dc.identifier.scopusqualityN/A
dc.identifier.startpage346
dc.identifier.trdizinid1370050
dc.identifier.urihttps://doi.org/10.18678/dtfd.1808654
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1370050
dc.identifier.urihttps://hdl.handle.net/20.500.12684/23317
dc.identifier.volume27
dc.identifier.wosWOS:001668974000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherDuzce Univ, Fac Medicine
dc.relation.ispartofDuzce Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260623
dc.subjectCadmium
dc.subjectChronic Kidney Disease
dc.subjectHemodialysis
dc.subjectPeritoneal Dialysis
dc.subjectInflammation
dc.subjectOxidative Stress
dc.subjectMalnutrition
dc.titleElevated Cadmium Levels in Dialysis Patients and Their Links to Inflammation, Oxidative Stress, and Malnutrition
dc.typeArticle

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