In vitro biocompatibility study approaches to evaluate the safety profile of electrolyzed water for skin and eye

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dc.contributor.authorSipahi, Hande
dc.contributor.authorReis, Rengin
dc.contributor.authorDinç, Özge
dc.contributor.authorKavaz, T.
dc.contributor.authorDimoglo, Anatoli
dc.contributor.authorAydın, Ahmet
dc.date.accessioned2020-04-30T23:18:27Z
dc.date.available2020-04-30T23:18:27Z
dc.date.issued2019
dc.departmentDÜ, Mühendislik Fakültesi, Çevre Mühendisliği Bölümüen_US
dc.descriptionDinc, Ozge/0000-0002-3029-7840; sipahi, hande/0000-0001-6482-3143; Reis, Rengin/0000-0002-3484-2201en_US
dc.descriptionWOS: 000476210100001en_US
dc.descriptionPubMed: 31303057en_US
dc.description.abstractElectrolyzed water (EW) is a widely used disinfectant agent with high oxidation-reduction potential (ORP). Although EW has been used in many areas, such as food hygiene, agriculture, and animal husbandry, the studies presented in the literature are not enough to clarify the toxic effects of EW. The aim of this study is, therefore, to produce EWs at different pH, ORP, and chlorine concentrations and to assess their safety in terms of toxicology. At the beginning of the study, the antimicrobial activity of the EW types with respect to bacteria and fungus was investigated. EWs below pH 7 were all effective in inactivating Enterococcus hirae, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans completely. In vitro studies of cell cultures revealed that different concentrations of EWs were not cytotoxic for the L929 cells under 10- to 80-fold dilutions. In addition, it has been determined that produced EWs did not have irritation potential, according to the in vitro EpiDerm((TM)), reconstituted skin irritation test in the frames of biocompatibility tests. For the mucous membrane irritation test, the hen's egg test-chorioallantoic membrane experiment was performed, and EWs were found to have no eye irritation. In conclusion, it has been shown that produced EWs with antimicrobial efficacy were found to be safe for skin and eye according to in vitro biocompatibility study studies. Thus, the establishment of a technological infrastructure for the EW production and the use of produced EW as an effective disinfectant in the food, medical, and agricultural areas should be encouraged.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) 1002 programTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [116Z169]en_US
dc.description.sponsorshipThe author(s) disclosed financial support for the research, authorship, and/or publication of this article: This project is financially supported by the Scientific and Technological Research Council of Turkey (TUBITAK) 1002 program (116Z169).en_US
dc.identifier.doi10.1177/0960327119862333
dc.identifier.endpage1326en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1314en_US
dc.identifier.urihttps://doi.org/10.1177/0960327119862333
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3325
dc.identifier.volume38en_US
dc.identifier.wosWOS:000476210100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiocidal activityen_US
dc.subjectdisinfectionen_US
dc.subjectelectrolyzed wateren_US
dc.subjectmucous membrane irritationen_US
dc.subjectskin irritationen_US
dc.subjecttoxicityen_US
dc.titleIn vitro biocompatibility study approaches to evaluate the safety profile of electrolyzed water for skin and eyeen_US
dc.typeArticleen_US

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