Association of omentin Val109Asp polymorphism with coronary artery disease

Basit Öğe Kaydı
dc.contributor.authorYörük, Ümit
dc.contributor.authorYaykaşlı, Kürşat Oğuz
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorMemişoğulları, Ramazan
dc.contributor.authorKarabacak, Ahmet
dc.contributor.authorBulur, Serkan
dc.contributor.authorKaya, Ertuğrul
dc.date.accessioned2020-04-30T22:39:54Z
dc.date.available2020-04-30T22:39:54Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionYaykasli, Kursat/0000-0001-7550-6370; Kaya, Ertugrul/0000-0003-0081-682Xen_US
dc.descriptionWOS: 000343521100005en_US
dc.descriptionPubMed: 24370683en_US
dc.description.abstractObjective: Coronary artery disease (CAD) is the most important morbidity and mortality disease in the world. It is also one of the leading causes of death in Turkey. Omentin, a recently found adipocytokine, is reported to regulate insulin sensitivity. It has anti-inflammatory properties and is inversely associated with CAD. Omentin gene polymorphism in patients with CAD has not been studied yet. The aim of this study is to investigate the relationship between omentin Val109Asp polymorphism and CAD. Methods: This is an observational study on genetic association. 157 consecutive patients who had undergone coronary angiography were included in the study. Seventy-five of them had CAD and the rest serves the control group. Val109Asp polymorphism was analyzed and compared. Chi-square test was used in comparison of genotype frequencies, whereas ANOVA and chi-square tests were used in comparison of clinical characteristics according to the genotypes. Results: There was no significant difference between CAD patients and control subjects regarding omentin Val109Asp polymorphism. However, a 2.5 fold increase in Val/Val (homozygous mutant) genotype was detected in patients with CAD. The OR (80% Cl) for Val/Val genotype was 3.46 (1.14-10.49). Conclusion: Although no significant difference was detected regarding omentin Val109Asp polymorphism, Val/Val genotype frequency was found to be more in patient group than control group. In conclusion, it may be speculated that Val/Val genotype increases the tendency for CAD, but this experiment should done with larger population to clarify this issue.en_US
dc.description.sponsorshipDuzce UniversityDuzce University [2011.04.HD.022]en_US
dc.description.sponsorshipThis project is supported by Duzce University Research Fund, Project Number 2011.04.HD.022.en_US
dc.identifier.doi10.5152/akd.2013.4932en_US
dc.identifier.endpage514en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage511en_US
dc.identifier.urihttps://doi.org/10.5152/akd.2013.4932
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2856
dc.identifier.volume14en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofAnatolian Journal Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectomentinen_US
dc.subjectpolymorphismen_US
dc.subjectPCR-RFLPen_US
dc.titleAssociation of omentin Val109Asp polymorphism with coronary artery diseaseen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
2856.pdf
Boyut:
97.07 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu