Effect of Rapamycin on Maternal Aggression in Rats

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dc.contributor.authorBeyazçiçek, Özge
dc.contributor.authorAnkaralı, Seyit
dc.contributor.authorBeyazçiçek, Ersin
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorDemir, Şerif
dc.date.accessioned2020-05-01T09:11:45Z
dc.date.available2020-05-01T09:11:45Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionAnkarali, Handan Camdeviren/0000-0002-3613-0523; Ankarali, Seyit/0000-0003-3752-0846en_US
dc.descriptionWOS: 000382113800002en_US
dc.description.abstractRapamycin which is an inhibitor of mammalian target of rapamycin (mTOR), has effects as antineoplastic, retarding aging, anti-inflammatory and neuroprotective. Aim of this study is to investigate the effects of rapamycin on maternal aggression in rats. In this study 63 Wistar female rats were used. The animals were divided into 3 groups: the solvent (DMSO) group, the 5 mg/kg rapamycin group, and the 10 mg/ kg rapamycin group. For behavioral testing the resident-intruder paradigm was used. The groups were compared in terms of the latency to the first aggressive behavior, the number of attacks, the total duration of aggressive behaviors and the intensity of attacks. When the groups were compared in terms of the latency to the first aggressive behavior, it was found that 5 and 10 mg/kg rapamycin groups were significantly prolonged latencies compared to the control group. When were evaluated the number of aggressive behaviors, total duration of aggressive behaviors and average severity of attacks it was found that 5 mg/kg rapamycin group's values were significantly lower than the control groups. These results show that acute administration of rapamycin, especially in 5 mg/kg dose of rapamycin prolongs the latency of maternal aggression, and decreased the number of attacks, the intensity of attacks and the total duration of aggressive behaviors in rats. Therefore rapamycin may have potential for use as a sedative drug, however it is necessary to conduct further studies.en_US
dc.description.sponsorshipDuzce University Research FundDuzce University [2013.04.01.197]en_US
dc.description.sponsorshipThis study was supported by the Duzce University Research Fund Project Number 2013.04.01.197. The study was presented orally at the 40th Physiology Congress (2-6 September 2014) in Erciyes University and published in congress abstracts book. We would like to thank to Joshua Tugumisirize, a psychiatrist in Islamic University in Uganda for his valuable comments and English editing.en_US
dc.identifier.doi10.9775/kvfd.2016.15336en_US
dc.identifier.endpage822en_US
dc.identifier.issn1300-6045
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage815en_US
dc.identifier.urihttps://doi.org/10.9775/kvfd.2016.15336
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5753
dc.identifier.volume22en_US
dc.identifier.wosWOS:000382113800002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMaternal aggressionen_US
dc.subjectRapamycinen_US
dc.subjectmTORen_US
dc.subjectRaten_US
dc.titleEffect of Rapamycin on Maternal Aggression in Ratsen_US
dc.typeArticleen_US

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