The Effects of Using Bioglue in Nasal Septal Surgery

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dc.authoridSubasi, Bugra/0000-0002-7666-612X
dc.contributor.authorSubasi, Bugra
dc.contributor.authorGuclu, Ender
dc.date.accessioned2021-12-01T18:48:18Z
dc.date.available2021-12-01T18:48:18Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractObjectives: Nasal septal surgery is one of the most common surgical procedure performed by otolaryngologists. Nasal packs are used for bleeding control, prevention of septal hematoma, replacement of mucoperichondrial flaps, and stabilization of the septum after nasal septal surgery. The aim of this study was to investigate the effects of albumin-glutaraldehyde-based tissue adhesive (Bioglue), which can be used as an alternative to nasal pack on the nasal septum after experimental nasal septum surgery. Methods: A total of 16 female Wistar albino rats were randomly separated into the study group (n = 10) and the control group (n = 6). After raising the mucoperichondrial flap on one side of the septum, Bioglue was used to fix the mucoperichondrial flap over the septal cartilage in the study group and nasal packs (Merocel) were used for fixation in the control group. The rats were sacrificed at 2 and 4 weeks after septoplasty. All the tissue samples were evaluated under light microscope by the same pathologist in respect of foreign-body reaction, degree of inflammation, granulation tissue, fibrosis, cartilage damage, and cilia and goblet cell damage. In the control group, the Merocel packs were removed after 2 days and the groups were compared in terms of hematoma. Results: No hematoma was observed in any group. Septal perforation was determined in all the study group participants and loss of cilia and goblet cells and foreign-body reaction were found in 8 samples of the study group participants and in none of the control group. Conclusions: The results of this study show that Bioglue caused segmental cartilage injury; therefore, it may not suitable for use following septal surgery.en_US
dc.identifier.doi10.1177/0145561321991349
dc.identifier.endpage521en_US
dc.identifier.issn0145-5613
dc.identifier.issn1942-7522
dc.identifier.issue7en_US
dc.identifier.pmid33559491en_US
dc.identifier.scopus2-s2.0-85101145326en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage516en_US
dc.identifier.urihttps://doi.org/10.1177/0145561321991349
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10503
dc.identifier.volume100en_US
dc.identifier.wosWOS:000673621000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofEnt-Ear Nose & Throat Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectnasal septumen_US
dc.subjectBioglueen_US
dc.subjectmucoperichondriumen_US
dc.subjectnasal packen_US
dc.subjectraten_US
dc.subjectGlutaraldehyde Tissue Adhesiveen_US
dc.subjectSurgical Adhesiveen_US
dc.subjectFibrin Glueen_US
dc.subjectRepairen_US
dc.subjectPreventionen_US
dc.subjectPackingen_US
dc.subjectCyanoacrylateen_US
dc.subjectSeptoplastyen_US
dc.subjectEfficacyen_US
dc.subjectFistulasen_US
dc.titleThe Effects of Using Bioglue in Nasal Septal Surgeryen_US
dc.typeArticleen_US

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