Polymorphisms in the promoters of MMP-2 and TIMP-2 genes in patients with acne vulgaris

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dc.contributor.authorYaykaşlı, Kürşat Oğuz
dc.contributor.authorTuran, Hakan
dc.contributor.authorKaya, Ertuğrul
dc.contributor.authorHatipoğlu, Ömer Faruk
dc.date.accessioned2020-04-30T23:21:05Z
dc.date.available2020-04-30T23:21:05Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionHatipoglu, Omer Faruk/0000-0002-1012-001X; Yaykasli, Kursat/0000-0001-7550-6370; Kaya, Ertugrul/0000-0003-0081-682Xen_US
dc.descriptionWOS: 000327588200015en_US
dc.descriptionPubMed: 24260605en_US
dc.description.abstractAcne, a chronic inflammatory skin disease, can be seen at any age but it most often occurs in adolescents and young people. Several factors, including increased sebum production, abnormal cornification of the pilosebaceous units, proliferation of Propionibacterium acne, and extracellular matrix (ECM) remodeling, are thought to be associated with the pathogenesis of the acne. The remodeling of the ECM is regulated by a balance between matrix metalloproteinases (MMPs) and their inhibitors called tissue inhibitors of metalloproteinases (TIMPs). The current study investigated the potential association between MMP-2 (-1306 C/T) and TIMP-2 (-418 G/C) polymorphisms and the risk for acne in a Turkish population. The study was conducted with 85 subjects who presented to the Dermatology Department of Duzce University Hospital. DNA was isolated from 2 ml of peripheral blood taken from each subject, and their genotypes were analyzed with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The CC, CT, and TT genotypes for MMP-2 (-1306 C/T) polymorphism were similar between the patient and control group (24 [55.8%], 17 [39.5%], and 2 [4.7%], respectively, vs. 21 [50%], 18 [42.9%], and 3 [7.1%], respectively). However, the distribution of the GG, GC, and CC genotypes for TIMP-2 (-418 G/C) polymorphism were different between the patient and control group (30 [69.8%], 9 [14.8%] and 4 [9.3%], respectively, vs. 26 [61.9%], 14 [33.3%], and 2 [4.8%], respectively). The results demonstrated that the TIMP-2 (-418 CC) genotype was nearly two times more common in the patient group compared to the control group (p=0.686, OR=1.45). It may be possible that the TIMP-2 (-418 CC) genotype increases the tendency to develop acne vulgaris by disrupting the balance between MMPs and TIMPs. Further investigations are needed to clarify more precisely the relationship between acne and MMP-TIMP genes.en_US
dc.identifier.endpage972en_US
dc.identifier.issn1940-5901
dc.identifier.issue10en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage967en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4132
dc.identifier.volume6en_US
dc.identifier.wosWOS:000327588200015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal Of Clinical And Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcne vulgarisen_US
dc.subjectMMPsen_US
dc.subjectTIMPsen_US
dc.subjectpolymorphismen_US
dc.titlePolymorphisms in the promoters of MMP-2 and TIMP-2 genes in patients with acne vulgarisen_US
dc.typeArticleen_US

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