The effect of peripheral dopamine on fracture healing: an experimental study in a rat model

dc.authoridyucel, Mucahid osman/0000-0002-9405-2367
dc.authoridDalaslan, Rasit Emin/0000-0001-5068-8024;
dc.contributor.authorYucel, Mucahid Osman
dc.contributor.authorDalaslan, Rasit Emin
dc.contributor.authorSaglam, Sonmez
dc.contributor.authorArican, Mehmet
dc.contributor.authorKaraduman, Zekeriya Okan
dc.contributor.authorTurhan, Banu
dc.contributor.authorDemir, Fatih
dc.date.accessioned2025-10-11T20:48:04Z
dc.date.available2025-10-11T20:48:04Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackgroundDopamine is a versatile biomolecule that functions as a neurotransmitter, hormone, and immune modulator in the body. Although some anabolic effects of dopamine on bone tissue have been described in the literature, its influence on the complex processes involved in fracture healing remains unclear. This study aimed to evaluate the effects of dopamine on bone healing at the peripheral level.MethodsThirty-six male Wistar albino rats were randomly assigned to two groups: a control group with no treatment and a dopamine group that received 12 mg/kg levodopa twice daily via oral gavage following surgery. A standardized femoral fracture was induced under anesthesia in all the rats, which were then fixed with an intramedullary Kirschner wire. Each group consisted of 18 rats, and six rats from each group were randomly sacrificed on postoperative days 15, 30, and 45. The harvested femurs were first evaluated radiologically, followed by biomechanical analysis via a three-point bending test, and finally subjected to histopathological examination.ResultsNo significant differences were observed between the groups on days 15 and 30. However, on day 45, histopathological scores were significantly lower in the dopamine group (p = 0.015), and biomechanical strength was also lower (p = 0.004). Radiological scores were not significantly different between the groups at any time point.ConclusionDespite the known anabolic effects of dopamine on bone cells, it may adversely affect fracture healing. The negative impact of dopamine on bone union could be attributed to the multifactorial and complex nature of fracture healing, the dynamics of inflammatory processes, and the cumulative effects of various dopamine receptor subtypes.en_US
dc.description.sponsorshipDuezce University Scientific Research Projects Coordination Unit under the Health Sciences Research Project Program (SBAP) [2024.04.02.1513]en_US
dc.description.sponsorshipThis research was supported by Duezce University Scientific Research Projects Coordination Unit under the Health Sciences Research Project Program (SBAP) (Project No: 2024.04.02.1513).en_US
dc.identifier.doi10.1186/s13018-025-06136-w
dc.identifier.issn1749-799X
dc.identifier.issue1en_US
dc.identifier.pmid40713746en_US
dc.identifier.scopus2-s2.0-105011686397en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s13018-025-06136-w
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21742
dc.identifier.volume20en_US
dc.identifier.wosWOS:001537395100005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofJournal of Orthopaedic Surgeryand Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectFracture healingen_US
dc.subjectDopamineen_US
dc.subjectLevodopaen_US
dc.subjectBone regenerationen_US
dc.subjectAnimal modelsen_US
dc.titleThe effect of peripheral dopamine on fracture healing: an experimental study in a rat modelen_US
dc.typeArticleen_US

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